Can I ask you nanonug what are you taking to try to lower histamine?
If you look at Figure 2 on the "
Histamine and histamine intolerance" paper, you'll see that there are two mechanism for histamine metabolism: one through diamine oxidase, the other through histamine N-methyltransferase.
Diamine oxidase is usually secreted in the stomach to help eliminate exogenous histamine, that present in food. On the other hand, the enzyme histamine N-methyltransferase is produced by pretty much every single cell in the body to degrade histamine "captured" through the various histamine receptors (H1 through H4, so far).
Right now, I am trying to get rid of excess histamine by both supplementing with diamine oxidase on an empty stomach, and overdriving the methylation cycle on which histamine N-methyltransferase depends. I take diamine oxidase on an empty stomach in an attempt to get it in the blood stream and subsequently degrade plasma histamine. I also take somewhat high dosages of TMG, methionine, methylfolate and methylcobalamin to overdrive the methylation cycle, thus supporting the histamine N-methyltransferase pathway.