the last published study listed in pubmed with a Marshall G named as author is:
Glaser R, Padgett DA, Litsky ML, Baiocchi RA, Yang EV, Chen M, Yeh PE, Klimas NG, Marshall GD, Whiteside T, Herberman R, Kiecolt-Glaser J, Williams MV. "Stress-associated changes in the steady-state expression of latent Epstein-Barr virus: implications for chronic fatigue syndrome and cancer."
Brain Behav Immun. 2005 Mar;19(2):91-103. PMID:
15664781
SourceDepartment of Molecular Virology, Immunology and Medical Genetics, The Ohio State University Medical Center, 333 W. 10th Avenue, Columbus, OH 43210, USA.
Abstract
Antibodies to several Epstein-Barr virus (EBV)-encoded enzymes are observed in patients with different EBV-associated diseases. The reason for these antibody patterns and the role these proteins might play in the pathophysiology of disease, separate from their role in virus replication, is unknown.
In this series of studies, we found that purified EBV deoxyuridine triphosphate nucleotidohydrolase (dUTPase) can inhibit the replication of human peripheral blood mononuclear cells in vitro and upregulate the production of TNF-alpha, IL-1beta, IL-6, IL-8, and IL-10.
It also enhanced the ability of natural killer cells to lyse target cells. The EBV dUTPase also significantly inhibited the replication of mitogen-stimulated lymphocytes and the synthesis of IFN-gamma by cells isolated from lymph nodes and spleens obtained from mice inoculated with the protein.
It also produced sickness behaviors known to be induced by some of the cytokines that were studied in the in vitro experiments. These symptoms include an increase in body temperature, a decrease in body mass and in physical activity.
The data provide a new perspective on how an early nonstructural EBV-encoded protein can cause immune dysregulation and produce clinical symptoms observed in patients with chronic fatigue syndrome (CFS) separate from its role in virus replication and may serve as a new approach to help identify one of the etiological agents for CFS.
The data also provide additional insight into the pathophysiology of EBV infection, inflammation, and cancer.
So if it is published, it hasn't made it to the pubmed listings.
http://www.reachmd.com/xmradioguest.aspx?pid=52279
His major research interests are focused on the effects of psychological stress and environmental factors on immune responses involved in various diseases including allergic rhinitis, asthma, inflammatory bowel disease and diabetes and the immunomodulatory effects of new therapeutic agents for allergy and asthma.
He has published over 100 peer reviewed articles, reviews and book chapters. He is an active speaker in regional, national and international venues. He has extensive editorial involvement with multiple journals and currently serves as editor-in-chief of the Annals of Allergy, Asthma and Immunology.
I don't feel too impressed with the stress association, although I'm sure CDC is thrilled.
