I am hetero 677 and have been taking methylation protocol for about 3 years. I got very little improvement in my cfs but continue to take it hoping that eventually I will come around. Well I got diagnosed with Lyme disease recently, which finally makes sense of the source of my cfs rather than mthfr. so I started doxy and have been taking it for about 2 months and then last week all of a sudden I starting feeling Overmethylation despite not changing my dose for methylfolate/mb12. I am getting that startup internal grinding trembling feeling. It's been happening for about a week and I end up having to take niacin which stops it quickly. I even stopped taking methylfolate for about a week and it is still happening !? Not sure if anyone here has Lyme too but I am wondering if the Lyme somehow inhibits Methylation and now that I am killing the bacteria suddenly there is a return of methylation. Can anyone figure out the connection?