-
Welcome to Phoenix Rising!
Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.
To become a member, simply click the Register button at the top right.
Anyone familiar with the IgA snps? Got some +/+
- Thread starter AkeBono
- Start date
Sea
Senior Member
- Messages
- 1,286
- Location
- NSW Australia
I have IgA deficiency. I don't think chronic infections lower IgA, it's the other way around. Low IgA predisposes to infections.
Rs9275224 AA 20%. I am AA
Rs2856717 homozygous AA ranges from 1% to 18% depending on ethnicity. I am AG
Rs9275596 homozygous CC ranges from 4% to 14%. I am CT
Rs9357155 homozygous AA is 1% to 4%. I am GG
Rs2412971 overall minor allele frequency is 44%. I am GG
Rs4728142 overall minor allele frquency is 29%. I am AG. This snp has reference to more research in OMIM from dbsnp. It has some association with SLE (lupus).
I can't see any reference to research about IgA deficiency from these snps.
This research
http://www.nature.com/srep/2014/140509/srep04904/fig_tab/srep04904_T1.html
suggests that the minor alleles of rs9275224, rs2856717, rs9275596 and rs2412971 are actually protective against IgA nephropathy
Rs9275224 AA 20%. I am AA
Rs2856717 homozygous AA ranges from 1% to 18% depending on ethnicity. I am AG
Rs9275596 homozygous CC ranges from 4% to 14%. I am CT
Rs9357155 homozygous AA is 1% to 4%. I am GG
Rs2412971 overall minor allele frequency is 44%. I am GG
Rs4728142 overall minor allele frquency is 29%. I am AG. This snp has reference to more research in OMIM from dbsnp. It has some association with SLE (lupus).
I can't see any reference to research about IgA deficiency from these snps.
This research
http://www.nature.com/srep/2014/140509/srep04904/fig_tab/srep04904_T1.html
suggests that the minor alleles of rs9275224, rs2856717, rs9275596 and rs2412971 are actually protective against IgA nephropathy
Sea
Senior Member
- Messages
- 1,286
- Location
- NSW Australia
I know that some get IVIG, but it is not something my doctors have shown any interest in treating. Mine was only tested as an aside really when I was being tested for Celiac antibodies, because a negative antibody test for Celiac is irrelevant if you are IgA deficient.
Criteria for being treated with IVIG varies in different countries. In Australia you have to have a number of documented infections per year and I think deficiencies in IgG as well as IgA
Criteria for being treated with IVIG varies in different countries. In Australia you have to have a number of documented infections per year and I think deficiencies in IgG as well as IgA