August 8th, 2018: Understanding and Remembrance Day for Severe ME
Have you heard of our Severe Myalgic Encephalomyelitis Day of Understanding and Remembrance? Please join Jody Smith in observing this day and honoring the 25% of those with ME/CFS who are most severely ill.
Discuss the article on the Forums.

Any investigation of post-exertion malaise?

Discussion in 'General ME/CFS Discussion' started by pcmenten, Mar 31, 2017.

  1. pcmenten

    pcmenten

    Messages:
    97
    Likes:
    157
    Vancouver, WA
    Just curious. Now that ME/CFS is recognized as having a physiological cause, I'm wondering what has been done to better characterize the causes of PEM. Seems like measuring the various symptoms might suggest a cause.
     
  2. Diwi9

    Diwi9 Senior Member

    Messages:
    976
    Likes:
    3,456
    USA
    From Dr. Lapp's summary of the 12th IACFS/ME conference (http://www.prohealth.com/library/showarticle.cfm?libid=30095):

     
  3. Wishful

    Wishful Senior Member

    Messages:
    821
    Likes:
    1,181
    That study sounds a bit flakey to me. Those seem to be very minor differences measured. Maybe it's real, but maybe it's just a side-effect of not having the mental energy to do the exercises properly. I probably use my muscles less efficiently while experiencing PEM just because I'm ignoring the feedback from my muscles.

    What I'd like to see is a complete profile of cytokines, kynurenines, mitochondrial function, and everything else measurable in serum--and more importantly--CSF.
     
  4. RYO

    RYO Senior Member

    Messages:
    296
    Likes:
    689
    USA
    The NIH intra mural study on ME/CFS will closely examine PEM. You can read about details of study in other threads. There is also youtube video - SolveCFS webinar with Dr. Avindra Nath who is the principal investigator for the study.
     
    Diwi9 likes this.

See more popular forum discussions.

Share This Page