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Any experience with Pyruvic acid supplementation? (Bad reaction)

Discussion in 'General Treatment' started by pattismith, Sep 13, 2018.

  1. pattismith

    pattismith Senior Member

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    I tried Pyruvic acid (calcium pyruvate 1500 mg per serving = 2 caps, 4 caps per day) supplementation for 36 hours now, and it is a bad failure for me....

    The bad effect starts 1h30 after the intake with big tinnitus, then after about 30 mn nausea and headache...

    I will not keep it!:ill:

    I didn't find anything on PR about other members experience about it, so I decided to report my short trial.
     
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  2. Shoshana

    Shoshana Northern USA

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    Northern USA
    Sorry that happened to you @pattismith :(

    But good for you to share that with others, here.
     
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  3. pattismith

    pattismith Senior Member

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    Don't be sorry Shoshana, hopefully, I recovered!:)

    Next time, perhaps I will be more lucky and will find something helpfull...Trial and errors...;)
     
    Shoshana likes this.
  4. pattismith

    pattismith Senior Member

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    I had Tinnitus as well from a drug that increases intracellular calcium, so i checked what is the effect on pyruvate on intracellular calcium:


    "Recent work reveals that pyruvate, the precursor substrate for the Krebs cycle, regulates Icrac to prolong Ca2+ influx into the cell, thereby coupling oxidation of glucose and its own metabolism in the mitochondria to Ca2+ influx by the CRAC channel."

    Increase of intracellular calcium is known to generate tinnitus...
     

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