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Anxiety And Depression Linked To Stress Causing Gut Bacteria

Discussion in 'Other Health News and Research' started by natasa778, Aug 11, 2015.

  1. natasa778

    natasa778 Senior Member


    Researchers exposed mice to early life stress by way of maternal separation. From age 3-days old to age 21-days old, the infant mice were separated from their mothers for three hours daily and then returned. The mice with complex gut bacteria that were separated from their mothers displayed more anxious and depressed behavioral characteristics, and also tested with abnormally high levels of the hormone corticosterone, a hormone that rises in the body in an attempt to calm anxieties.

    The mice also showed increased disturbed gut function as shown by a disruption in acetylcholine, a neurotransmitter that has recently been thought to be the primary cause of depression.

    According to Premysel Bercik, primary author of the study, neonatal stress increases stress and disturbed gut function. This changes the gut bacteria, which then interrupts the proper functioning of the brain...
    Marco, Thinktank and ahmo like this.
  2. lansbergen

    lansbergen Senior Member

    And what exactly is that disruption?????
  3. sarah darwins

    sarah darwins I told you I was ill

    Cornwall, UK
    Here's the abstract from Nature Communications (full paper is paywalled):


    There's some interesting stuff in here, and an interesting interview with the lead author, Premysel Bercik, here: [looks like an interesting site for anyone wanting to know more about microbiome research], though I do wish Bercik and others would get on with a bit more human research. From the interview:

    "It’s difficult to apply this directly to humans." Yeah, no kidding. They're mice.
    Sasha likes this.

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