nanonug
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5611980/
Recently, coffee has been recognized as an effective beverage for healthful aging, especially with respect to maladies such as cardiovascular disease [1] and mild cognitive impairment [2]. Moreover, several human studies have revealed that habitual coffee intake reduces the all-cause mortality in Japanese and several other population groups [3,4] and mortality from heart disease and cerebrovascular disease [3]. Coffee contains caffeine and many kinds of polyphenols. Caffeine has several effects on aging, especially through inhibiting the mammalian target of rapamycin (mTOR) complex 1 (mTORC1) and prolonging the life span of fission yeast [5]. Moreover, the polyphenol chlorogenic acid has many beneficial effects, e.g., lowering fat accumulation in diet-induced obese mice by downregulating sterol regulatory element-binding protein 1 [6]. These studies indicate that one of the most consumed beverages, coffee, has potential anti-aging effects that contribute to the prevention of age-related diseases. However, the mechanisms and effects of coffee are not fully understood with respect to aging or age-related diseases.