Over the years of my illness, I have tried many different drugs: digestive (pancreatin, bile), prebiotics and probiotics, prokinetics (itopride, domperidone), antacid and acid (esomeprazole, acidin-pepsin), enveloping and anti-inflammatory (flax seeds, bismuth subcitrate, gastritol), helicobacter antibiotics, choleretic and cholekinetics, hepatoprotectors (thiotriazolinum, s-adenosylmethionine), sedatives and nootropics (Hypericum, valerian, ginkgo biloba, alimemazine, phenibut, glycine, hopantenic acid, GABA, salbutamine, 5-HTP), antidepressants (mirtazapine, sertraline, fluoxetine, bupropion), vitamins and trace elements (C, B1, B2, B3, B6, B9, B12, magnesium). I also experimented with naltrexone. None of this helps me. I am constantly tormented by discomfort in the right hypochondrium, whatever I do. I underwent all kinds of research and my official diagnosis was chronic gastro-duodenitis and Helicobacter, which I treated without any changes. I also constantly feel tired, brain fog and depression, which are aggravated in the evening. Comrades, can you advise something from medicines that I have not tried yet?