I have done reasonably well during the past 1,5 years. With methylation protocol, tons of supplements, gluten-free (paleo-ish, organic) diet, amalgam removal and chelation etc etc etc. I've gone from 25-30% functionality to a solid 60-65%. I work 20h/ week and take care of my two small children (and husband), BUT, I would really like to see some improvement in terms of my dysfunctioning immune system. I have had long periods of constant infections, you know, catching every single bug around and being sick from october to april, like non-stop. Then I have had other periods (mainly when being pregnant) when I did not get any infections, but still felt "fluey" all the time (ME-symtoms). In any case, even though I am doing reasonably well right now I am sick of getting sick with back-to-back infections during the past four (winter) months. When my kids catch a cold/flu, I will get it 4-5 days later. Without exception. and I will be as sick as a dog, for exactly three weeks. Then enjoy 1-2 "good weeks" and then get sick again. Sure, it's all part of being a parent, but no other parent I know get as many infections as me. Even though I tested negative for a couple of viruses and bugs (lyme, EBV and mycoplasma etc) when I got my ME/CFS diagnosis, I have strong reasons to believe that I do have chronic/hidden viruses that cause me problems. I have been taking LDN for the past 4 months, (up to 3mg/day) and have some improvemnt in energy/stamina, I think, however, still very much prone to infections. I added Inosine (pulsing protocol) about 1+ month ago) and perhaps its working...This is the first time I didn't catch my dauthers cold....*fingers crossed* now to my question: I am tempted to try transfer factors....but I need input and advice....please respond if you have anything to say about transfer factors or general advice on immuno modulators etc. Thanks!!!