I feel there's a connection between certain pro-inflammatory substances like histamine and a rise in adrenalin / noradrenalin. Whenever i take a H1 inhibitor during an "hyperadrenergic" episode it calms me down and reduces inflammation. When i take a beta blocker it does calm me down but the inflammation stays. Using a beta2 agonist reduces my allergic / mcas symptoms. So... antagonizing H1 receptors = decrease in adrenalin / noradrenalin? With less histamine binding to its receptors the body senses less need for adrenalin/noradrenalin. The same goes for cortisol, low cortisol drives high adrenalin/noradrenalin. Please correct me if i'm wrong.