Gondwanaland
Senior Member
- Messages
- 5,092
@Wonkmonkhttps://www.ncbi.nlm.nih.gov/pubmed/25292432
Acyclovir
Acyclovir is primarily eliminated by renal excretion. However, approximately 8.5–14.1% of the drug is metabolized by ADH to acyclovir aldehyde, which in turn is metabolized through ALDH to 9-carboxymethoxymethylguanine (CMMG) (96, 97). With impaired renal function, acyclovir renal elimination is limited, and the drug is primarily metabolized. When 1,000 mg of the acyclovir prodrug valaciclovir was given orally in Japanese patients with
end-stage renal disease, the acyclovir half-life was significantly altered by the ALDH2 genotype; patients with an ALDH2*2/*2 genotype had a prolonged half-life 8.6 h longer on average than those with an ALDH2*1/*1 genotype (26.7 h versus 18.1 h). These data suggest that metabolism of acyclovir and valaciclovir is mediated by ALDH2 (98).
@Learner1 Would taking NAD+ and Molybdenum help?