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A comparative polysomnography analysis of sleep in healthy controls and patients with CFS

Discussion in 'Latest ME/CFS Research' started by Kyla, Apr 28, 2016.

  1. Kyla

    Kyla ᴀɴɴɪᴇ ɢꜱᴀᴍᴩᴇʟ

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    http://www.tandfonline.com/doi/abs/10.1080/21641846.2016.1167470

     
    Last edited: Apr 28, 2016
  2. MeSci

    MeSci ME/CFS since 1995; activity level 6?

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  3. barbc56

    barbc56 Senior Member

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    I'm wondering if the sleep issues are a cause or effect of mecfs. I have had sleep issues my whole life.

    My doctor says there are some indications that RLS may mean you are predisposed to eventually getting FM but it hasn't been proven. Plus, not everyone who has RLS ends up getting me/cfs.

    Maybe it's indicative of a dysfuncting nervous system?

    Are there other illnesses with similar sleep profiles?
     
  4. Valentijn

    Valentijn Senior Member

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    Prior to ME, I got excellent sleep. 9-10 hours, always felt well-rested.
     
  5. barbc56

    barbc56 Senior Member

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    Maybe I should do a poll. Not that it would be rigorous evidence but more out of curiosity.

    I do have to say, since getting sick, these sleep problems became much worse.

    Sometimes I think I've never awakened feeling refreshed, even as a child. That's an exaggeration of course but it's certainly been a consistent pattern in my life.
     
  6. MeSci

    MeSci ME/CFS since 1995; activity level 6?

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    I have had sleep problems most of my life too, but ME/CFS only (obviously at least) for the last 21, out of 61.
     
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  7. ukxmrv

    ukxmrv Senior Member

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    I slept really well before I got ME. We were always a family of night owls and when I got ME that got much worse. I wouldn't rank the sleep problems I have as a major symptom though apart from waking unrefreshed which started overnight with the acute onset viral ME.

    As I have said before on other threads it is as if "something" resets in my overnight that leaves me worse in the morning than when I went to bed.

    Still remember what it was like though to wake refreshed and full of energy and go outside in the sun on a beautiful morning to bring the milk bottles in.

    Not experienced that for over 30 years now and I miss it.
     
    Last edited: Apr 29, 2016
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  8. Little Bluestem

    Little Bluestem All Good Things Must Come to an End

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    I slept well before ME. I think the poor sleep is an effect rather than a cause of the disorder. It contributes significantly to my debility, though, and treating it would make me feel better.
     
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  9. Dolphin

    Dolphin Senior Member

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    I don't believe they do any so group analyses to see whether this makes any difference.
     
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  10. Dolphin

    Dolphin Senior Member

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    I think a retrospective survey of sleep problems might have problems. Some people could have had mild ME but not have been diagnosed. I was undiagnosed for over 5 years. For the first 4 years of those I was fairly high functioning (full-time education at a high level). The biggest problem from me was I couldn't exercise and had lots of muscle problems (if I had not been so sporty before becoming ill my sedentary lifestyle might have seemed normal). I recall never feeling I got enough sleep. So the sleep issues seem to be there even with the mildly affected unlike some other symptoms.
     
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  11. Dolphin

    Dolphin Senior Member

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    Nearly all of the data is in tables 2 & 3. Table 1 explains the acronyms.
     
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  12. Belbyr

    Belbyr

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    I slept well before ME too. No issues whatsoever.

    Could be that our sympathetic tone is upped with this illness. I have elevated levels of norepinephrine while lying and even higher when standing. (This was one of the POTS tests at Mayo Clinic)
     
  13. Dolphin

    Dolphin Senior Member

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    The differences were for sleep onset latency P= .06 and number of awakenings was P= .08.

    Numerically the sleep onset latency was an average of 28.95 minutes for the CFS group and 14.73 minutes for the control group i.e. nearly double for the CFS group.
     
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  14. Dolphin

    Dolphin Senior Member

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    This is a self-report questionnaire.

    It was P equals .07 for medication use. However to take part in the study you needed to be free from any sleeping medication for at least 3 weeks prior to the recording so the sample may be biased.

     
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  15. Dolphin

    Dolphin Senior Member

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    This testing was done in people's homes.
     
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  16. Dolphin

    Dolphin Senior Member

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    They had been concerned that readings from their 2nd night might not give accurate results. This is because people often sleep poorly on the 1st night of testing and then there can be a rebound effect on the 2nd night where people catch up with missed sleep from the 1st night.
     
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  17. Dolphin

    Dolphin Senior Member

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    The total sleep times recorded in a diary and by objective measurements were almost exactly the same: 448.68 minutes versus 453.91 minutes.

    Sleep onset latency was recorded in a diary as 33.95 minutes but was only 22.47 minutes by objective measurements. These results did not correlate statistically.

    The average minutes awake after sleep onset were recorded in the diary is 41.58 minutes but were were measured objectively as 37.13 minutes. These results did not correlate statistically.
     
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  18. Dolphin

    Dolphin Senior Member

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    By symptoms they mean fatigue symptoms. Possibly also pain symptoms as one of the subscales of the SF 36 looks at pain.

     
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  19. Dolphin

    Dolphin Senior Member

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    They mentioned this in the list of outcome measures but then don't mention it again it seems to me from both reading it and now searching for Ford in the text
     
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  20. Dolphin

    Dolphin Senior Member

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