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A 50,000 Foot Overview of Major ME/CFS Theories

Discussion in 'General ME/CFS Discussion' started by Jesse2233, Nov 15, 2017.

  1. Jesse2233

    Jesse2233 Senior Member

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    Hey guys - thought it might be interesting to list out all the major ME/CFS causal theories in one place.

    This can act as a primer for newbies, and as a way to look at everything in a comprehensive manner in the hopes of making fresh connections.

    I’ve tried to keep each theory to one simple sentence. Let me know if I’ve left out or grossly misstated anything important.

    ——————————

    Enlightened GPs / laypublic - post-infectious non-specific immune dysfunction

    Unenlightened GPs / laypublic - psychological construct / wastebasket diagnosis

    Melvin Ramsay - polio-like illness following an enterovirus infection

    John Chia - chronic non-cytolytic enterovirus infection

    Byron Hyde - diffuse lower brain injury following enterovirus infection

    Martin Lerner - chronic abortive herpes family infection

    Kenny De Meirleir - inflammatory gut dysbiosis following tick-born illness

    Jay Goldstein - post-infectious central sensitization of the brain

    Jose Montoya - chronic HHV infection of the CNS

    Carmen Scheibenbogen - autoimmunity against muscarinic and adrenergic receptors

    Robert Naviaux - cell danger response mediated by purinergic signaling

    Ron Davis / Fluge + Mella - a large molecule in serum disrupting cellular metabolism

    Mark Davis - nonspecific antigen causing inflammatory T-cell dysfunction

    Sarah Myhill - multicausal dysfunction of various mitochondrial mechanisms

    Neil McGregor / Chris Armstrong - genetic susceptibility to gut dysbiosis causing sepsis-like metabolic state

    Ritchie Shoemaker / Joseph Brewer - mold causing immune dysfunction

    Jarred Younger - chronic microglial inflammation

    Rich Van K / Fred Davis - blockage in glutathione production

    Michael Van Elzakker - chronic infection of the vagus nerve

    Martin Pall - dysfunction of the nitric oxide cycle

    Garth Nicholson - chronic mycoplasma pneumonia infection

    Peter Behan - enterovirus driven autoimmunity against ATP translocator

    Andy Cutler - chronic heavy metal toxicity

    Judy Miktovas - chronic XMRV / HERV infection

    William Weir - chronic non-specific retrovirus infection

    Cecil Jardin - chronic non-specific bacterial infection

    Gupta / Hooper / Neuffer - non-specific autonomic dysfunction

    Chalder / White / Wesely / Parker - self-limiting fear based beliefs

    The 1980s - Candida

    The 1990s - EBV

    ——————————

    Some PR theories

    @necessary8 - autoantibody to CD38 causing metabolic dysfunction through eATP

    @Jonathan Edwards - 6+ subtypes involving immune sensitization, autoimmunity, and chronic inflammation

    @mariovitali - suboptimal liver function leading to immunological / metabolic dysfunction
     
    Last edited: Nov 15, 2017
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  2. MartinDH

    MartinDH Senior Member

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    A good overview of the absurdity of trusting in a doctor's theory and treatment plan.
     
  3. ivorin

    ivorin Senior Member

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    Makes me sad how spot-on this is - we really are nowhere for the moment.
     
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  4. wastwater

    wastwater Senior Member

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    Dr kerr (genes)dr edwards (B cell)and dr Wright lymes might be others as well
    And the many potential treatments
    I think it’s to do with tumour suppressor pathways and unregulated interferon
     
    Last edited: Nov 15, 2017
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  5. alex3619

    alex3619 Senior Member

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    Lipkin has a proposal relating to a subgroup, post encephalitis consequences.
     
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  6. ivorin

    ivorin Senior Member

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    Do you have a link to this please? It sounds like my subgroup and I haven't heard of it before.
     
  7. alex3619

    alex3619 Senior Member

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    It was in his recent paper on classical and atypical ME, as he calls them. Many of us are encephalitis survivors. This also fits with several theories of ME. I do not have a link handy and need to nap right now.
     
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  8. Countrygirl

    Countrygirl Senior Member

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    No wonder I have felt so wretchedly ill! Sheesh! :ill::aghhh:

    Also:

    Organochlorine poisoning. (Book written on it by he London Hazard's Centre about 25 years ago of which I have a copy..........somewhere.

    Organophasphate poisoning which includes sheep dippers' flu and aerotoxic syndrome.

    ME caused by septrin (Uk) .in the 90s compensation was paid to people with ME who had developed ME after courses of the antibiotic. It re-emerged as bactrim in the US.

    According to my GP, ME is caused by sleeping on a mattress that is past its best. :rolleyes:
     
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  9. wastwater

    wastwater Senior Member

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    Wasn’t there something about breast implants causing cfs as well
     
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  10. garcia

    garcia Aristocrat Extraordinaire

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    I think some may be confusing causal theories / mechanisms with triggers. E.g. Dr Myhill deals extensively with Organophasphate poisoning and aerotoxic syndrome. IMHO those aren't causal theories but triggers (for e.g. mitochondrial dysfunction).
    Also I don't think Dr Kerr ever proposed that altered gene expression as the underlying cause? Why is gene expression altered? Also Dr Wright was never wedded to lyme, but followed a "pathogen zoo" approach.
    IMHO the list should be kept to genuine hypotheses which cover actual possible causal mechanisms.
     
    Last edited: Nov 15, 2017
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  11. Countrygirl

    Countrygirl Senior Member

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    Yes, there was. :thumbsup:
     
  12. Countrygirl

    Countrygirl Senior Member

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    I agree with this I think it seems that ME is the result of a double whammy, of which OPs play a significant part in recent years in the UK.

    Certain vaccinations like Hep B are notorious triggers too.
     
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  13. alex3619

    alex3619 Senior Member

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    The trigger/causation issue is a big problem. There do however appear to be subtypes, at least two, so there might be multiple causative mechanisms ... or not. Then we have risk factors like EDS.

    The trigger/causation issue is why we have doubts and theories about post pathogen syndromes like polio, giardia and Lyme. Are they different? Variations? Subgroups? Or just different triggers, with some pathophysiogenic variation due to the different triggers?
     
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  14. CFSTheBear

    CFSTheBear Senior Member

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    What I find slightly odd is the amount of patients that you see wedded to a particular idea of what ME/CFS is, when threads like this show that there isn't anything close to a medical consensus in the first place.
     
    Last edited: Nov 15, 2017
  15. pattismith

    pattismith Senior Member

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    why doesn't he publish his theory, it would save so much money and energy looking at complicated hypothesis:rofl:
     
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  16. alex3619

    alex3619 Senior Member

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    The weirdest theory has to be not being pregnant. Which would mean us guys have no chance.
     
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  17. perrier

    perrier Senior Member

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    What was Dr Kerr's postulate? I once spoke with him on the telephone: kind empathetic man.

    Brilliant work Jesse!
     
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  18. soti

    soti Senior Member

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    I wonder how many subsets of these are (or can be made) consistent with each other.
     
  19. Jesse2233

    Jesse2233 Senior Member

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    Probably most of the biomedical ones
     
  20. Gingergrrl

    Gingergrrl Senior Member

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    I know both of these (plus several other auto-antibodies and factors) are a huge part of my own case but whether this is ME/CFS, or I am just a freak of nature remains to be seen... Great work Jesse ;)
     

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