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Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.
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For those seeing positive results with LDN, what dose are you on? Did you start at that dose or work up to it? Did you experience a flare of symptoms in the beginning which disappeared as you continued?
I have positive effects at a very low dose (.5mg), I worked my way up to 2.5mg at one point but I started getting depressed and extremely sleepy during the day (shift from my cfs-norm of tired/wired). This went away when I went way back down.
I had mild sleep disturbance when I started (and at significant dose increases) but this went away and I sleep better now because I have less pain.