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23andMe results- let the journey begin!

Discussion in 'Genetic Testing and SNPs' started by goonie8473, Nov 1, 2014.

  1. goonie8473


    Hello - I recently discovered this site and am excited to find such a helpful and knowledgeable community. I've been researching natural ways to treat lifelong symptoms of depression, mood swings, anxiety and brain fog and am delving deeper into supplementation, methylation and genetic testing.

    I received my results back from 23andMe; this is a complicated journey but I am trying to figure out the initial steps and treatments for these genetic anomalies. This forum (and have been excellent resources so far, but I am at a bit of a loss of what to address first! And as to what combinations of gene defects can be tricky. Any insights or suggestions for what to look into would be greatly appreciated.

    My results are below; the ones that seem most concerning are MTHFR a1298c homo, MAO A R297R hetero, CBS 699T homo.

    COMT V158M rs4680 GG -/-
    COMT H62H rs4633 CC -/-
    COMT P199P rs769224 GG -/-
    VDR Bsm rs1544410 CC -/-
    VDR Taq rs731236 AA +/+
    MAO A R297R rs6323 GT +/-

    ACAT1-02 rs3741049 GG -/-
    MTHFR C677T rs1801133 GG -/-
    MTHFR 03 P39P rs2066470 GG -/-
    MTHFR A1298C rs1801131 GG +/+
    MTR A2756G rs1805087 AG +/-

    MTRR A66G rs1801394 AA -/-
    MTRR H595Y not found n/a
    MTRR K350A rs162036 AA -/-
    MTRR R415T not found n/a
    MTRR A664A rs1802059 GG -/-
    BHMT-02 rs567754 CC -/-
    BHMT-04 not found n/a
    BHMT-08 rs651852 CC -/-
    AHCY-01 rs819147 TT -/-
    AHCY-02 not found n/a n/a
    AHCY-19 rs819171 TT -/-
    CBS C699T rs234706 AA +/+
    CBS A360A rs1801181 -- no call
    CBS N212N not found n/a
    SHMT1 C1420T not found n/a n/a

    Symptoms: lifelong depression, anxiety and mood swings (worsened significantly for 1-2 weeks around my period/PMS-induced and debilitating at times). Brain fog, fatigue, low stamina; not all of the time, but more often than not and seem to correlate to my period, lack of sleep, stress, and occasionally caffeine consumption (16oz cup every day). Have tested for low iron previously. Tested low-ish for vitamin D, which I know is related to VDR?). I am 28/F, 120lbs.

    Current daily supplements:
    -fish oil (minami 850mg omega 3, 45mg omega 6, 35mg omega 9)
    - vit b12 (~125-250mg jarrow methylb12, which I believe is the proper form for MTHFR)
    - vit c (500mg+)
    - vit d (upped to 2,000 iu)
    - few times per week: Thorne Mediclear Plus powder- which seems to have a lot of helpful ingredients in general and the proper forms of b12 and folate as well as molybedum)
    - evening primose oil (500mg, sometimes 1,000mg around period)
    - zinc (50 mg as amino acid chelate)
    - probiotics (either udo's choice or pb8)
    - magnesium/calcium blend (Solaray ~700 mg mag citrate/oxide and cal citrate/hydroxide).

    I also take effexor 75mg daily and the occasional adderall xr 5mg (the latter makes me feel like a real person!). For diet, I focus on protein, fats, and am low-gluten, low-grain, low-sugar but have some slip ups. I eat greek yogurt every day and drink a lot of kombucha & mineral water.

    Thank you in advance for any insights and I look forward to speaking to more of you on this forum!
    Last edited: Nov 1, 2014
  2. Gandalf


    Hey goonie. To me it looks like you're already all set regarding your mutations.
    And I hope the stuff you take has a great positive impact.
    As for your Brain fog, fatigue and low stamina you might want to look into supplements which increase your energy metabolism. In the brain as well as in the body.
    Here are just a few keywords: Piracetam, Lipoic acid, Creatine

    Good luck!
  3. Methyl Health

    Methyl Health

    @goognie8473 - You look like you have my genes and I had all of your issues. Except the PMS cause I am a dude.

    You need to be careful about the coffee, but not about the caffeine. Coffee has a HUGE amount of riboflavin. Roboflavin is great for MTHFR but it speeds up the Methionine cycle and effects the CBS SNP by producing too much homocysteine and therefore too much action down the transulfuration pathway. Trust me on this, you need to make sure you fix the CBS SNP first of you will be frustrated.


    I would add pyridoxal 5 phosphate (B6) for that CBS SNP. Does wonders for me. I need to take B6 before I drink decaf coffee of I get brain fog and rhinitis badly. In fact it is the first subligual I take in the morning and my day is great.

    I was hospitalized twice with severe anxiety and depression. It has been 10 years since I have been hospitalized and three months since I have had any depression or anxiety and I am on zero pharmaceutical meds. That is huge for me. I credit this this to understanding my SNPs.

    As far as the addreal is concerned, yes, speed will always make most people feel better. ;)

    My homozgous SNPs....

    BTD - rs13078881

    Cystathionine β-synthase
    CBS C699T - rs234706

    Methyltetrahydrofolate Reductase
    MTHFR A1298C - rs1801131
    MTHFR - rs1476413
    MTHFR - rs3737964
    MTHFR - rs4846048
    MTHFR - rs484604

    Betaine-homocysteine methyltransferase
    BHMT-08 - rs651852

    5-methyltetrahydrofolate-homocysteine methyltransferase reductase
    MTRR A66G, rs1801394

    TCN1 - rs526934,GG
    TCN2 C766G - rs1801198

    Beta-Carotene Dioxygenase
    BCMO1 - rs656485

    Monoamine Oxidase
    MAO A R297R - rs6323
    MAO-A - rs2072743
    MAO-B - rs1799836
    MAO-B - rs2283729

    COMT V158M - rs4680
    COMT H62H - rs4633
    COMT -rs4646312

    Angiotensin 1 Converting Enzyme
    ACE Del16 - rs4343

    Phosphatidylethanolamine N-methyltransferase
    PEMT - rs7946
    PEMT - rs4646406

    Fatty acid desaturase 1
    FADS1 - rs174537

    Glutathione S-transferase P
    GSTP1 (GCH1) - rs1695

    Superoxide Dismutase 2
    SOD2 A16V - rs4880
    SOD2 - rs2758331
    SOD2 - rs10370

    Glucose-6-phosphatase 2
    G6PC2 - rs560887

    Fucosyltransferase 2
    FUT2 - rs492602
    FUT2 - rs601338
    FUT2 - rs602662

    Glutamate Decarboxylase 1
    GAD1 - rs3749034

    Cytochrome P450 Genes
    CYP1B1 L432V - rs1056836
    CYP2D6 S486T - rs1135840
    CYP1A1 - rs2606345
    CYP1A2 - rs72547513

    Major Histocompatibility Complex, Class II, DP Beta 2
    HLA-DPB2 / COL11A2P - rs1883414
    victoriana likes this.
  4. goonie8473


    Apologies for the late reply, but thank you both for the very helpful suggestions!

    Methyl Heath, that is fantastic to hear that you have addressed your depression/anxiety and are no longer on the meddy-go-round. So many people struggle with those both severely and it's inspiring to hear that people can recover in ways that western medicine doesn't yet understand.

    I will definitely try the p5p for CBS. And perhaps try switching to decaf coffee-- it is almost the same, right? :)
  5. kel88

    kel88 Senior Member

    Ive got almost the same mutations as u @goonie8473 and u @Methyl Health...

    Look at my signature. Also a1298c and CBS homozygous!
  6. Darrin


    I have the same mutation and have to eat every hour and a half. Do you have any blood sugar problems?

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