Invisible Illness Awareness Week 2016: Our Voices Need to Be Heard
Never heard of Invisible Illness Awareness Week? You're not alone. Jody Smith sheds a little light to make it more visible
Discuss the article on the Forums.

‘Off switch for pain’: scientists find new way of shutting down pain

Discussion in 'Other Health News and Research' started by Bob, Nov 27, 2014.

  1. Bob

    Bob

    Messages:
    10,703
    Likes:
    34,256
    England (south coast)
    ‘Off switch for pain’: scientists find new way of shutting down pain
    27 November 2014
    The Independent
    http://www.independent.co.uk/news/s...nd-new-way-of-shutting-down-pain-9888339.html

    And here's a more scientific article...

    'Off switch' for pain discovered: Activating the adenosine A3 receptor subtype is key to powerful pain relief
    November 26, 2014
    Science Daily
    http://www.sciencedaily.com/releases/2014/11/141126132639.htm
     
  2. Bob

    Bob

    Messages:
    10,703
    Likes:
    34,256
    England (south coast)
    This is the research paper...

    Endogenous adenosine A3 receptor activation selectively alleviates persistent pain states
    Joshua W. Little et al.
    First published online: 20 November 2014
    Brain
    DOI: http://dx.doi.org/10.1093/brain/awu330
     
  3. lansbergen

    lansbergen Senior Member

    Messages:
    2,511
    Likes:
    2,728
    Critically, engaging the A3AR mechanism did not alter nociceptive thresholds in non-neuropathy animals and therefore produced selective alleviation of persistent neuropathic pain states.

    So this could explain the difference between ME pain and injury pain?
     
    Bob likes this.
  4. Navid

    Navid Senior Member

    Messages:
    515
    Likes:
    435

    Are there clinical trials in the US using these?

    thanks, Navid
     
  5. Sean

    Sean Senior Member

    Messages:
    3,263
    Likes:
    18,044
    Off switch for pain.

    That would be nice. :cool:
     
    Bob likes this.
  6. adreno

    adreno PR activist

    Messages:
    4,841
    Likes:
    11,080
    I don't think that can be concluded. It means that normal animals did not lose/change their ability to feel pain - which is critical. You don't want to lose your sense of pain, or you'll end up cutting your finger off, or worse.
     
    Valentijn likes this.
  7. lansbergen

    lansbergen Senior Member

    Messages:
    2,511
    Likes:
    2,728
    But it helped for neuropatic pain?
     
  8. adreno

    adreno PR activist

    Messages:
    4,841
    Likes:
    11,080
    Yes, it helped with chronic, neuropathic pain.
     

See more popular forum discussions.

Share This Page