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‘Genetic scalpel’ can manipulate the microbiome, Yale study shows

Gondwanaland

Senior Member
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5,092
https://news.yale.edu/2017/04/20/genetic-scalpel-can-manipulate-microbiome-yale-study-shows
The gut microbiota is implicated in numerous aspects of health and disease. In this video, Andrew Goodman’s group present a powerful system to modulate gene expression of a common member of the human microbiota in vivo inside the gut by providing an inducer molecule in drinking water.
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The team used these tools to understand how pathogens dine off sugars that microbiome bacteria strip from the gut wall in their search for food. By controlling the timing and extent of this activity, the researchers were able to measure how long these leftovers remain available for pathogens. The findings help explain how antibiotics counterintuitively increase the levels of these delicacies for pathogens and may one day help create more effective infectious disease therapies, the authors say.