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    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

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    Folic Acid level decreasing even after supplementation. Could be MTHFR?

    Hi, I regularly take 3MG of Methylfolate daily and an Iron Tablet, still both have decreased to borderline low. I have no genetic mutations related to these. I am completely clueless. Please help. Thanks
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    Folic Acid level decreasing even after supplementation. Could be MTHFR?

    @alicec Hey thanks for your reply. Can these mutations cause premature hair graying? Thanks
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    Folic Acid level decreasing even after supplementation. Could be MTHFR?

    Hey, many thanks for your reply. How much would these mutations affect my lifestyle? Do they really affect or affect is minimal? My doctor told me not to take Folic acid, only Methylfolate but my multi has 400MCG of Folate but I really don't want to leave it because except Folic Acid, it has...
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    Folic Acid level decreasing even after supplementation. Could be MTHFR?

    Hey, So I now have my genetic report. I have mutations in these genes: MTHFD1 || c.1958G>A (p.Arg653Gln) || Autosomal Recessive || Heterozygous MTRR || c.66A>G (p.Ile22Met) || Autosomal Recessive || Homozygous No MTHFR mutation. How do those mutations affect? I take a multivitamin having 400...
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    Folic Acid level decreasing even after supplementation. Could be MTHFR?

    Hey guys, I have a good news. After trying everything, but no success, I increased my doses from 800 MCG MethylFolate/day to 2400 MCG/Day and it worked. Just in two days, the new levels are: VITAMIN B6/P5P [LC-MS/MS] 39.66 ng/ml (5 - 50) VITAMIN B9/FOLIC ACID [LC-MS/MS] 0.21 ng/ml (0.2 - 20)...
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    Folic Acid level decreasing even after supplementation. Could be MTHFR?

    Hey guys, it has been 20 days since I am taking 800 MCG MethylFolate and it has shown 0 improvements. I don't know why my Folic acid level is going down. 16th Dec, 2016 - VITAMIN B6/P5P [LC-MS/MS] 28.78 ng/ml (5 - 50) VITAMIN B9/FOLIC ACID [LC-MS/MS] 0.24 ng/ml (0.2 - 20) VITAMIN B-12...
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    Folic Acid level decreasing even after supplementation. Could be MTHFR?

    Thanks for your reply :) I do not have Anemia, Hypothyroidism, or Lupus. Not sure about Celiac. I do not have PEM. I feel more energetic after exercise. After reading all the symptoms, I do not think I have CMF (I have chronic cough, but it's negligible, doesn't affect my day to day life at...
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    Folic Acid level decreasing even after supplementation. Could be MTHFR?

    Many thanks for your reply. I am already taking 10,000 IU Vitamin D. I was deficient 2 months ago (17 ng/ml), but now my levels are 45 ng/ml (30-100). I actually feel very good after working out. I read the criteria. post-exertion malaise lasting more than 24 hours - No. unrefreshing sleep...
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    Folic Acid level decreasing even after supplementation. Could be MTHFR?

    I am not sure. I love working out, there is no pain in my muscles. I do have forgetfulness, I often forget name of things or people but I also topped my school last year. I have low confidence though. I also feel extremely tired and low some days, not everyday though. I have improved ALOT after...
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    Folic Acid level decreasing even after supplementation. Could be MTHFR?

    That is possible. I'll have another test soon. I am getting depressed, angrier and more irritated day by day. I cannot go to a doctor because they say "It's just your mind".
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    Folic Acid level decreasing even after supplementation. Could be MTHFR?

    Supplements were taken at least 15 hours before each test so I don't think this is the case. Chances are that it's serum. I'll ask the lab anyway and will let you know. BTW, I have ordered the test. Costed me about 670 USD. Will give blood tomorrow and will get results in a month. I will keep...
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    Folic Acid level decreasing even after supplementation. Could be MTHFR?

    Thanks for your reply. I have already ordered Jarrow's Methylfolate. Do you think I could have MTHFR mutation? It costs about $800 here to get it tested, that's why I want to make sure before get tested.
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    Folic Acid level decreasing even after supplementation. Could be MTHFR?

    (If it's in the wrong section, please move it.) Hey, My test results: 1st Nov, started supplementing Folic acid, 800 MCG/day 18th Nov, 2016 - VITAMIN B6/P5P [LC-MS/MS] 4.02 ng/ml (5 - 50) VITAMIN B9/FOLIC ACID [LC-MS/MS] 0.6 ng/ml (0.2 - 20) VITAMIN B-12 [C.L.I.A] 251 pg/ml (211 - 911)...