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    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

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  1. G

    Large dose of Milk Thistle causes worsening for 1 week, then relief for 1 week

    How long did Milk Thistle work for you?
  2. G

    Large dose of Milk Thistle causes worsening for 1 week, then relief for 1 week

    I took a couple of grams. I'm just really confused about why it caused me to to go from worse to better, then back to baseline. You'd think that a supplement is going to either be good or bad, not alternating between both.
  3. G

    Large dose of Milk Thistle causes worsening for 1 week, then relief for 1 week

    I can't figure out why this is happening. Maybe it's a detox reaction then relief? But then why do I return to baseline 2 weeks after dosing? Any ideas guys?
  4. G

    Glutamate and Depression

    Glutamate based depression has been rising in notoriety. This theory of depression is well known in the CFS & ME community, as high glutamate often accompanies CFS & ME. It's also often seen in Alzheimers, Benzo/ Alcohol withdrawal, Huntington's disease, and a few others. I've attached a link...