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    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

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  1. G

    Help understanding homozygous mutations in both COMT and BHMT?

    Thanks for this. I will go via promethease and see what else turns up, and Magnesium and Zinc sound like a good place to start. Do you know which form of Magnesium might be best? Iron levels are fine, as is serum folate (and as I don't supplement with folic acid I assume that these should be...
  2. G

    Help understanding homozygous mutations in both COMT and BHMT?

    Hi all, Getting my 23andme results has opened up a whole new and fascinating world for me, but my brain is now frazzled from all of the new information and I don't even know where to start with supplements due to all the contra-indications! I've not been feeling well for some time, am knackered...