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    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of and finding treatments for complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia (FM), long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

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  1. ZeroGravitas

    Efthymios’s AI aided protocol

    I wonder if I should switch to UDCA for similar reason; taurine (on its own) has previously given me next day fatigue. As well as testing very high one time. Of course, most pwMEcfs are low in taurine and benifit from taking it. But my methylation SNPs may be causing my sulphur intake to drain...
  2. ZeroGravitas

    Efthymios’s AI aided protocol

    Same with sulphur supps (and goitrogens - sulphurous veg, even). But don't get any characteristic sulphite intolerance symproms. Just next day spacey fatigue, as with most things. My taurine appeared naturally high (vs all other aminos), seemingly from draining/backed up sulphur metabolism...
  3. ZeroGravitas

    Efthymios’s AI aided protocol

    So, I've been discussing liver/ER stress with Efthymios/MarioVitali elsewhere and trying it on for size as a framework of self-treatment. Given my past (10 years ago) difficulty with tolerating any phase 2 detox substrate amino acids, some slightly elevated liver enzymes, etc (I forget). I...
  4. ZeroGravitas

    Amsterdam scientists find an enzyme (IDO2) that could be the culprit of #LongCovid: Prolonged IDO2 activity & associated cellular stress in PASC.

    OK, cool. So PASC patients with higher kynurenine pathway metabolites in their blood had worst cognitive impairment? Neat. And, sorry. I probably won't get back to adding more analysis on the above papers, etc. Bit off more than I can chew, there and getting a little overwhelmed with many...
  5. ZeroGravitas

    Amsterdam scientists find an enzyme (IDO2) that could be the culprit of #LongCovid: Prolonged IDO2 activity & associated cellular stress in PASC.

    I'll have a go (please correct me!) at a more detailed breakdown of how these two papers contradict Phair's tryp-trap, expanding on point (A), above: (1) The PASC patient's PBMCs (monocytes/lymphocytes), which are able to express IDO2, contained high kynurenine and *low* tryptophan. Although...
  6. ZeroGravitas

    Amsterdam scientists find an enzyme (IDO2) that could be the culprit of #LongCovid: Prolonged IDO2 activity & associated cellular stress in PASC.

    OK, back to the main points! (I know you've updated your thinking on these, Junk.) My letter indexes: (A) No. This does support OMF's continued interest in tryp & kynurenine. But many observations, and the proposed mechanism, directly contradict Phair's original tryp-trap hypothesis. Although...
  7. ZeroGravitas

    OMF Kynurenine trial

    I don't think I was following closely enough to be sure of the reason... But, yeah, it definitely seemed like drawing a line under the tryp-trap as his most promising possibility. Although, the yeast experiments seemed to work out fine, the Itaconate Shunt could maybe cause a tryp-trap (via...
  8. ZeroGravitas

    Sport inhibits IDO, maybe a basis for PEM?

    I searched my way to this interesting thread 🙂 after looking for more info on AhR (aryl hydrocarbon receptors). Which are proposed as a key part of the massively increased IDO2 expression and kynurenine production reportedly found in certain cells of PASC patients, in this new Dutch paper. The...
  9. ZeroGravitas

    OMF Kynurenine trial

    Is the info in the left side bar of this OMF website page the most up to date..?: So, things didn't look as expect and resources were shifted to other investigations. But animal models may still be in play...? Is that top point what Dr Phair was referring to back in Dec 2020, here?: I'm...
  10. ZeroGravitas

    Amsterdam scientists find an enzyme (IDO2) that could be the culprit of #LongCovid: Prolonged IDO2 activity & associated cellular stress in PASC.

    IDO2 expression is not actually downregulated in Phair's tryp-trap hypothesis. So I don't think it's necessarily incompatible with the new study, in this regard... 🤔 IDO2's enzymatic activity is inherently lower (or absent) in most humans, due to various common deleterious mutations. These were...
  11. ZeroGravitas

    High dose vitamin B1 (thiamine)

    Oh, erm. I feel like I've seen it said elsewhere too... But I think I can only reference info I think I got off you! 14% of their (n=87) patients with CFS (in that 1998 paper) met the criteria for phosphate diabetes. Dysfunctional phosphate reabsorption in kidneys, I think..? A potentially...
  12. ZeroGravitas

    High dose vitamin B1 (thiamine)

    Which types of magnesium have you tried? It's personal, but glycinate and taurate give me fatigue. Citrate other issues. Malate I had to stop after years due to new joint and neck issues. Orotate is currently good. Otherwise, sorry, I don't have many similarities/insights with your experience...
  13. ZeroGravitas

    Near Infrared Light (940nm) Improves COVID Outcomes.

    Oh nice! Hah. That's a huge saving, if there's no compromise in function.👍 But, to be honest, I wasn't considering the spotlights so much. How do you use yours, if I may ask? Do you litterally just illuminate your head? To treat brainfog topically (do you consider it should penetrate the...
  14. ZeroGravitas

    High dose melatonin

    Here is the UK option: Thanks for link. I kinda love how their "suggested use" instructions of 1mg per night mean the single 20 Euro pouch has enough melatonin for 2 lifetimes! With its total of 50'000 servings. Seems legit. 😅 Anyway. This month, Loh updated her acute (e.g. Covid) infection...
  15. ZeroGravitas

    High dose melatonin

    I *was* planning to try this soon. I imported 300mcg melatonin capsules from Nootropics depot, ready... But now I have acute Covid for first time.😑 After a day or two of hypersomnia, I've gone polyphasic myself. Two sleeps per day. If your sleep periods don't tend to aggregate, on their own...
  16. ZeroGravitas

    Near Infrared Light (940nm) Improves COVID Outcomes.

    This blog post by Ruth (on My Invisible World) was talking about NIR lamp use for ME/CFS back in 2018. Ahead of the curve by my reconing, maybe on par with Hip..? She also describes an optimal/max dose, around 10-15 min (depending). This feature of NIR exposure surprised me a lot; after...
  17. ZeroGravitas

    Anyone tried Black Seed Oil?

    And... Yep. LFT today showed strong positive for covid. Sorry gang. 😳 This despite wearing an FFP2 everywhere outside my room. And despite not having any flu or colds at all for over a decade. Pressumably an odd coincidence. Or confluence (if BSO is immunomodulating).
  18. ZeroGravitas

    Anyone tried Black Seed Oil?

    Incidentally, one of the reasons I'm trying BSO, aside from it being an acclaimed cure-all I've not taken before, is that there was speculation it might lower TNF-alpha. As a reason it might have helped someone with delayed sleep: I've not seen any other evidence for this as yet. Or...
  19. ZeroGravitas

    Anyone tried Black Seed Oil?

    I titrated, over a few days, up to one capsule of Nootropics Depot Nigella Sativa 200mg (5% thymoquinone), as of a coule days ago. Now I have mild flu-like symptoms - very slight: headache, limb soreness, phlem, now shivering so wrapped up extra warm, only 38C (in-ear), resting heart rate...
  20. ZeroGravitas

    Itaconate Shunt (now called INFa-Itaconate shunt) Part 2!

    Convergence is great.:)👍 Will this tie in with his recent talk of a non-novel biomarker? 🙂 Are you able to clarify what this might involve, yet? 🙂 From what I searched up quickly, "cell-autonomous" might relate to recycling cytoplasmic components, such as defective organelles or protein...
  21. ZeroGravitas

    High dose melatonin

    Loh responded to me on Twitter, a year ago, to say the opposite, that small amounts have a prooxidant effect: I'd used 1/4mg (or less) melatonin on and off for years, following a specialist prescription for my non-24-hour sleep. But got groggy/depression/fatigue next day from 1/2mg. Never...
  22. ZeroGravitas

    Majority of nicotinamide mononucleotide (NMN) supplements contain virtually no NMN!

    Ahh. I was about to retry my NMN Plus that did nothing for me 18 months ago. Guess I'll just bin it directly and buy anew from Nutropics Depot (or Jarrow, etc).😅 Thank you kinda Hip, great information. :thumbsup:
  23. ZeroGravitas

    Anyone else get brainfog/lethargy from malic acid?

    Personally, I found (18 months back) that magnesium malate (probably), which I'd been taking for many years, started causing me new joint discomfort and elbow locking up... ... Which resolved after reducing it back to one tablet/day. But then I had to remove malate entirely, 9 months back, for...
  24. ZeroGravitas

    Anyone else get brainfog/lethargy from malic acid?

    Did you mean this?: Higher in that thread, there was speculation that malate might be useful like the experimental Oxaloacetate treatment:
  25. ZeroGravitas

    Itaconate Shunt (now called INFa-Itaconate shunt) Part 2!

    OK, so, few months back, Phair explained that the IDO trap might potentially be triggered by the IFNa itaconate shunt (but not vice versa):
  26. ZeroGravitas

    Itaconate Shunt (now called INFa-Itaconate shunt) Part 2!

    Thanks for summary and thread. The feel of this video talk was quite interesting. Phair perhaps seemed more confident in what he was saying (than a couple years ago). And quite specific about the source of IFNa serum signal coming from the cells around the site of an initial infection. Also...
  27. ZeroGravitas

    ME/CFS Metabolomic Study Points to a Potential Cause of Mitochondrial Dysfunction

    See previous thread where this study was posted (Jan 2022). Probably best to continue this discussion there instead..? Even earlier thread where a previous version of the same paper (with a different title) was discussed in greater detail (July 2021): "Dysregulation of the Kennedy Pathway and...
  28. ZeroGravitas

    ADHD may skew towards slower onset of ME/CFS - my Reddit polls comparison

    Yes, that's the only way you have ADHD (as discussed above). He does not have ME/CFS. I don't. But generally you'll react to specific things, with allergy type symptoms, various skin issues like hives, etc, many of the high histamine symptoms, which are many, complex and reduced by lowering your...
  29. ZeroGravitas

    ADHD may skew towards slower onset of ME/CFS - my Reddit polls comparison

    That's exactly what I thought a decade ago... ...Which I got too; it was like having Kleine Levin syndrome for the two days I took the starting dose, sleeping 20 hours per day. GP was quite alarmed. Although it's a pretty well know reaction. Histamine used in the wakefulness centre of the...
  30. ZeroGravitas

    ADHD may skew towards slower onset of ME/CFS - my Reddit polls comparison

    I'm interested in iron, currently, having had a private (Thriva) test that showed it was low, despite optimal normal ferritin. It's hard to know how long that's been an issue for, given that it won't have shown up on any previous NHS tests, given it's not been severe enough to show anaemia...