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    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

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    Please help me understand my 23andMe results

    Well as if MTHFR and MAO mutations are not enough, I just found out that I am Apo E3/E4 which seems to indicate increased risk for impaired cholesterol metabolism and AD:cautious:...Any suggestions to mitigate these factors?
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    Please help me understand my 23andMe results

    The article addresses the carnitine component which is a known TMAO precursor (a reason I temper my lecithin consumption which also is a potential TMAO booster when metabolized), not creatine ?
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    Please help me understand my 23andMe results

    No problem - I am 33 now. Never tested my sodium levels but I decreased my salt intake over the last 2 yrs after switching from junk food laden with sodium&simple carbs to almost complete exclusion of them today. But my bp has always been 110-120/70-80 before that. Perhaps I was too young to...
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    Please help me understand my 23andMe results

    Thank you for your suggestions, Gandalf. I already cut out all of the gluten and take 100mg/d of R-ALA but I will add creatine. I will reconsider DMAE, thanks. I read some negative reviews about piracetam so it scared me enough to not touch it.
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    Please help me understand my 23andMe results

    No - usually it is ~115/65. It went down a bit from 120/80 after adopting the pescetarian diet which, from what I have read, is a normal consequence with the lower (animal) fat intake.
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    Please help me understand my 23andMe results

    Thank you for your reply, Tania! I am a male - is baby aspirin suggestion applicable to men with this MTHFR mutation too?
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    Please help me understand my 23andMe results

    Thank you @caledonia for chiming in. I looked into the Guide - highly helpful resource, thanks for putting it together. OK, I will lower the niacin dose. I had no idea about MTHFR C677T +/+ until 2 days ago when I received my 23andMe results. Given my MAO R297R +/+, how much 5HTP would be...
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    Please help me understand my 23andMe results

    Thank you so much for sharing your thoughts, Bosco!!! I take 500mg Niacin (as nicotinic acid) for HDL cholesterol boost/LDL control. I do have occasional anxiety episodes but meditation helps to stay more or less on even keel. Does this mean that I need to opt for hydroxyB12 instead of...
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    Please help me understand my 23andMe results

    Hello everyone, I wonder if anyone would be kind enough to help me make sense of my 23andMe results. I am completely new to the whole genetic stuff but I am learning so please bear with me. From other posters, I see that you need my methylation and detoxification results via genetic genie as...