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    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

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    CBS Upregulation Confusion (Yasko Contradiction, Cysteine, Heavy Metals, etc)

    @Cheesus - Sounds like you're more up to speed than you think. :) Specifically which single thiols are problematic (that we can control)? Not sure which belong in that group... I would assume Cysteine, since AC specifically mentions thiol avoidance if you have high Cysteine. However, I've been...
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    CBS Upregulation Confusion (Yasko Contradiction, Cysteine, Heavy Metals, etc)

    @Cheesus - Thanks for the response. I would like to chelate and worry about the Glutathione later, but it seems that it's kind of a package deal. Glutathione is produced to detoxify heavy metals, etc, so if it's absent, my fear is the DMSA, etc. is wasted. @Valentijn - I respect your opinion...
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    Taurine & Beta-Alanine

    How are you guys feeling Taurine? I'm not sure about the low cellular Taurine theory, but it's possible. I have supplemented with Taurine in the 1000 - 1500 mg day range for a couple of years with no noticeable difference. Since I posted this, Ive gotten a new doc. He's gotten me off of all...
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    CBS Upregulation Confusion (Yasko Contradiction, Cysteine, Heavy Metals, etc)

    Quick back story...... I am currently being treated for heavy metals toxicity. I have tested slightly elevated for lead and mercury on a provoked urinary heavy metals test/challenge. My first doc thought the levels weren't significant enough to be concerned about, so we spent two years battling...
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    Quercetin

    I have read good things about quercetin from antimicrobial benefits to potential dopamine enhancement. However, I just came across (as reported by @ahmo) that it is a high thiol / sulfur substance. Due to CBS upgregulation and BHMT defects, I am to be very strictly avoiding thiols during my...
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    Taurine & Beta-Alanine

    I had a NutraEval done late last year. The biggest findings for me were the following: - Very Low Riboflavin (B2) - Low Niacin - Extremely high (urinary) Taurine. 3x higher than the top of range - High Beta-Alanine - Very high Tartaric Acid (indicative of intestinal dysbiosis) Since the Amino...
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    Diagnosis Unclear After 15 yrs

    I haven't focused much on the histamine piece accept to supplement methylfolate and other methylating compounds. My whole blood histamine at my last test was ideal. Ryan
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    Diagnosis Unclear After 15 yrs

    That means Lithium Orotate actually appears to inhibit histamine. As an "undermethylator", I have higher histamine levels than most, so LO would actually be a good substance for this purpose. In regards to pyrroluria, I agree that the testing sucks. I have taken Zinc dosages up to 300 mg per...
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    Diagnosis Unclear After 15 yrs

    Thanks leela. I have read some of Pfeiffer's work, but not this book. I struggle with his theories though. My functional MD has me on treatment for high histamine (undermethylation). Also, he tested my pyrroles (HPU/KPU), and they came back borderline, but I put my self on high zinc (about 150...
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    Diagnosis Unclear After 15 yrs

    Thanks for the response Amho. From what I am reading, it appears that LO is more of a histamine antagonist than anything. It should be reducing the effects of histamine if anything. Is that what you were saying?
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    Diagnosis Unclear After 15 yrs

    This is my first post here. I have spent a lot of time reading threads and trying to absorb it. I have seen about 10 psychiatrist and several holistic MDs at this point. I have had brain scans at Amen Clinic in California. If you have had success treating the symptoms I describe, I would greatly...