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    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

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  1. Z

    supplemental 5-MTHF versus egg yolks

    Thanks for the responses. @minkeygirl, The filler idea is a good one, but I have experimented at some length and am fairly certain that I am not sensitive to excipients -- though I am ultra-sensitive to certain active ingredients, for sure! @whodathunkit, Thanks for sharing your experience...
  2. Z

    supplemental 5-MTHF versus egg yolks

    I reported a bad experience supplementing 5-MTHF and m-B12. I've tried to reintroduce 5-MTHF many times since with consistently negative results, even at less than 100mcg per day. Experiments with low-dose TMG have also been very unpleasant. As much as I try to convince myself that @Freddd...
  3. Z

    Why would B12+folate cause GABA to reverse its effect?

    @Violeta, This is a compelling idea -- and my best guess at present, too! My plan, when I get up the nerve to try m-B12 + 5-MTHF again, is to take larger daily doses of the other Bs, especially B2. The first time around, I kept dosages very low, mainly because of claims by @Freddd that...
  4. Z

    Why would B12+folate cause GABA to reverse its effect?

    @Violeta, Thank you for your many contributions to this thread. Sorry for my delay in responding! I wish I knew what to say about histamine. No question, it became a big problem after I got sick -- but so did other things, such as tyramine, purine, and, above all, glutamate. I suddenly...
  5. Z

    Why would B12+folate cause GABA to reverse its effect?

    Thank you, everyone, for the responses. What a generous community this is! I am doing better now, but it took quite a few days after stopping 5-MTHF + B12 for things to start calming down, and I am still not back, by a long way, to where I was before I started. I remain entirely confused as...
  6. Z

    Why would B12+folate cause GABA to reverse its effect?

    Hello, everyone. I've been lurking for a long time, but this is my first post. I finally did the Health Diagnostics methylation panel, which showed low reduced glutathione, high oxidized glutathione, low SAM, high SAH, and low folate at every step of its path. I took this as a green light to...