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    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

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  1. M

    COMT says don't take methyl MTRR says DO take.....

    Glad to hear you are feeling better :) I definitely got a small spike in energy just before from the methyl -b12 despite taking the hydroxyl b12 all this week. I am still confused about whether I can tolerate methyl donors. Seem to have trouble with methyl folate when I have taken it in the past...
  2. M

    COMT says don't take methyl MTRR says DO take.....

    I have a similar conundrum. I am heterozygous for MTRR and COMT, so I am not really sure which are expressing. I have a lot of problems with anxiety and fatigue. What are the clues to find out which genes are expressing? After reading your post, I am experimenting today with some high dose...