Do supportive supplements increase methyation need?

[OneToughCanary]

I started with a minimalist approach (MB12 and Mfolate) but have begun to supplement some things like B1/B complex and potassium/electrolytes. Those things have been of benefit, but they've caused other issues, most notably depression and/or anxiety/nervousness. I removed niacin from the equation in case it was soaking up too much methyl, but I'm still getting the issues. I seem to get improvement by upping my B12 and/or folate beyond what I'd been doing. Is that typical? I.e., do adding in Bs and/or electrolytes open up pathways that cause the B12 and folate to be used up more quickly, hence you need to supply more of them (a blessing since the goal is to be upping those)?

 

[Eastman]

@OneToughCanary

The symptoms that you described are not uncommon in those who do methylation treatment. See, for example, this thread: Consider this before you go down the MTHFR self-treatment rabbit hole.

In my post in that thread, I suggested that it was methylation treatment itself that might have caused the symptoms and that supplements like B1 and B3 might be able to provide relief.

B1 may also increase folate and B12 uptake. That could help you use these nutrients more effectively. On the other hand, according to Freddd, it could also induce paradoxical folate deficiency.

 

[pamojja]

I started with a minimalist approach (MB12 and Mfolate) but have begun to supplement some things like B1/B complex and potassium/electrolytes. Those things have been of benefit, but they've caused other issues, most notably depression and/or anxiety/nervousness

It's always good to take at least a bit of all other B-vitamins, if one goes high with one or two. If it caused unwanted side-effects, I would reduce the doses.

B-vitamins utilization is just so intricately interwoven: