Any experience with Pyruvic acid supplementation? (Bad reaction)

[pattismith]

I tried Pyruvic acid (calcium pyruvate 1500 mg per serving = 2 caps, 4 caps per day) supplementation for 36 hours now, and it is a bad failure for me....

The bad effect starts 1h30 after the intake with big tinnitus, then after about 30 mn nausea and headache...

I will not keep it!

I didn't find anything on PR about other members experience about it, so I decided to report my short trial.

 

[Shoshana]

Sorry that happened to you @pattismith

But good for you to share that with others, here.

 

[pattismith]

Sorry that happened to you @pattismith

But good for you to share that with others, here.

Don't be sorry Shoshana, hopefully, I recovered!

Next time, perhaps I will be more lucky and will find something helpfull...Trial and errors...

 

[pattismith]

I had Tinnitus as well from a drug that increases intracellular calcium, so i checked what is the effect on pyruvate on intracellular calcium:


"Recent work reveals that pyruvate, the precursor substrate for the Krebs cycle, regulates Icrac to prolong Ca2+ influx into the cell, thereby coupling oxidation of glucose and its own metabolism in the mitochondria to Ca2+ influx by the CRAC channel."

Increase of intracellular calcium is known to generate tinnitus...