Thiamine Deficiency uncovered

[sregan]

I was so focused on minerals I completely overlooked something.

For the last few months I've been experiencing low energy, feelings of adrenal fatigue and just general feeling of going downhill and nothing I can do about it. Again... something is very wrong.

For the second time in as many years I have been experiencing pretty severe alcohol intolerance. I wrote about it click here. I had a stressful holiday season and assumed my cortisol levels were bottomed out again.

I started searching again and I have no idea how I missed this last year but vitamin B1, Thiamine, is the most likely place to look.

Taking 100mg each morning with my regular B's and multi Mineral and so far so good. I've got energy and feeling very good and positive!

I'm not sure why I was low on Thiamine to begin with. Wondering if methylation supplements can do that? Or possibly lack of Folate?

 

[mariovitali]

Check a Gene called SLC19A3

 

[Learner1]

I'm not sure why I was low on Thiamine to begin with. Wondering if methylation supplements can do that? Or possibly lack of Folate?

Thiamine is used in the transsulfuration pathway, along with molybdenum, to help rid the body of toxins mobilized in methylation. So, if you increase your methylation supplements, your need for B1 will increase.

B1 also maintains the muscle tone in the walls of the digestive tract and promotes the health of the nervous system, skin, hair, eyes, mouth, and liver. and it improves the body’s ability to withstand stress. So, if these needs to go up you will need to get it from somewhere.

My body seems to need about 700mg a day of B1, per my symptoms and lab testing

 

[bjl218]

What would you say are the typical symptoms of low B1? I sometimes have trouble discerning the difference between the symptoms of too much B12/folate, too little B2, too little B1. Although I guess the symptoms might be different for everyone.

 

[sregan]

Check a Gene called SLC19A3

Thanks for that. I pulled up my genonme on 23andme and there's like 20 rows for this Gene. Apparently 19A2 is onvolved somehow. Do you know what rs# I'm looking for and what is the normal state for?

I can take Thiamine and it does help.

I found this: https://livewello.com/library/thiamine-metabolism-dysfunction-slc19a3?id=5307915007164416

looks like a lot to sift through. I'll keep digging...

 

[sregan]

How can I make sense of this?

Genes Marker (SNP) Genomic Position Variants Your Genotype
SLC19A3 rs12105737 228550429 C or T - T / T
SLC19A3 rs13025803 228552709 C or T - C / C
SLC19A3 i5006222 228552932 C or T - T / T
SLC19A3 rs4973216 228561253 C or T - C / T
SLC19A3 i5006224 228563473 C or G - C / C
SLC19A3 rs12185721 228563675 C or T - C / C
SLC19A3 rs11694828 228565656 A or G - G / G
SLC19A3 i5006223 228566905 C or T - T / T
SLC19A3 rs6713116 228567098 C or T - C / T
SLC19A3 rs932134 228567907 C or T - C / T
SLC19A3 rs7567984 228567967 C or T - C / C
SLC19A3 rs11682956 228568652 G or T -G / T
SLC19A3 rs17372264 228569190 C or T - C / T
SLC19A3 rs7585761 228570875 A or G - A / G
SLC19A3 rs6708238 228571475 C or T - C / T
SLC19A3 rs10933203 228572770 A or C - C / C
SLC19A3 rs10933204 228577663 A or G -G / G
SLC19A3 rs7585481 228577809 C or T - C / T
SLC19A3 rs17372407 228578891 C or T -C / T

 

[sregan]

Thiamine is used in the transsulfuration pathway, along with molybdenum, to help rid the body of toxins mobilized in methylation. So, if you increase your methylation supplements, your need for B1 will increase.

B1 also maintains the muscle tone in the walls of the digestive tract and promotes the health of the nervous system, skin, hair, eyes, mouth, and liver. and it improves the body’s ability to withstand stress. So, if these needs to go up you will need to get it from somewhere.

My body seems to need about 700mg a day of B1, per my symptoms and lab testing

I've been having IBS-D issues for a while now... I thought taking 100mg would be a lot although I've read that when low Doctors prescribe 500mg per day. Do you find that taking such high B1 depletes other cofactors?

Are you taking other cofactors?

 

[sregan]

What would you say are the typical symptoms of low B1? I sometimes have trouble discerning the difference between the symptoms of too much B12/folate, too little B2, too little B1. Although I guess the symptoms might be different for everyone.

For me I just feel ill, old, run down, fragile, no energy. Typical CFS I would say. Adrenal fatigue for sure.

 

[sregan]

So maybe here: http://www.geneticlifehacks.com/thiamine-genetic-variations-in-need-for-b1/

Out of the three Snps below I only have informaiton for rs28937595 which is ok @ C/C

An SLC35F3 (thiamin transporter) variant is linked to hypertension. There have been other studies showing that thiamine supplementation reduces blood pressure in some, possibly due to the increase in pyruvic and lactic acid found in thiamine deficiency.[ref] [ref]

• rs17514104 (not in 23andme) – A is minor allele. Those homozygous for the minor allele (AA), had a significant reduction in blood thiamine content and higher blood pressure. [ref]

SLC19A2 is the gene that codes for the Thiamine transporter 1. Mutations in this gene can cause thiamine-responsive megaloblastic anemia.

• rs28937595 – AA is considered pathogenic for thiamin-responsive megaloblastic anemia.[ref]
• rs121908540 – TT is considered pathogenic for thiamin-responsive megaloblastic anemia. (23andMe v5 only)

 

[Learner1]

I've been having IBS-D issues for a while now... I thought taking 100mg would be a lot although I've read that when low Doctors prescribe 500mg per day. Do you find that taking such high B1 depletes other cofactors?

Are you taking other cofactors?

Yes, I am on a comprehensive program with all the cofactors, customized according to my labs.

 

[Learner1]

What would you say are the typical symptoms of low B1?

Poor appetite, weight loss, colitis and ongoing digestive problems like diarrhea, nerve damage and inflammation, fatigue, decrease in short-term memory, heart complications, and psychosis.

 

[bjl218]

Wow. Ok, so I'm guessing I'm not suffering from severe B1 deficiency...

@Learner1, you may have mentioned this previously, but what labs are you doing to monitor your nutrient status (other than NutrEval) and how often do you do these labs?

 

[Learner1]

I do the NutrEval every 9-12 months. In between, my doctor will check MCV, homocysteine, various RBC minerals, and an amino acid panel through LabCorp. But they're not a substitute for the NutrEval. I also had an OAT test recently.

While there's some overlap with the NutrEval, there are things unique to each trst, like lipids and antioxidants on the NutrEval.