frozenborderline
Senior Member
- Messages
- 4,405
Welcome to Phoenix Rising!
Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.
To become a member, simply click the Register button at the top right.
This doesn’t make a lot of sense to me either. I wonder if there is something in the full paper that explains it better. I will look.If you can trigger autism with Ampligen, so I don't understand why it couldn't also create CFS/ME in adult...:thumbdown:
This makes it (a little) clearer, I think: https://paolomaccallini.wordpress.com/2016/09/02/ampligen-rituximab-and-hypometabolism/
one of the reasons i'm interested is that I only had the bands that usually indicate past infection, but my CFS doctor is into the lerner protocol and thinks that those high IgG or IGM--i forget which?? bands indicate current infection. Well so far i'm only getting worse on antivirals. So i was curious about what the researchers I respect most have to say about itThis is interesting, although those statements were discussed here back in 2016. Naviaux and Davis don't believe viruses play a big part, but lots of CFS/ME doctors think otherwise. There is a big trial going on by Pridgen et al. (primarily for fibromyalgia) that investigates use of Famvir+Celebrex combo and apparently there are some promising results upcoming. One patient who had CFS/ME for 26 years got into remission after a couple of months on this protcol. If those viruses play no part, then there should not be any recoveries from chronic diseases with Pridgen protocol, but apparently there are.
The biggest oversight I think is the focus on viruses. We know q fever can cause me cfs, and there is always the Lyme question too. My own ME was triggered by yersinia, so I would hope that the researchers are open to such possibilities.
It's nice to ear he is studying PCR for virus in ME/CFS patients, but it is something our docs can't do, it would mean taking samples in our body (lymph nodes, nervous system, muscles) that are not easy to take (blood is not enough).
It is actually very unusual to be PCR positive to herpes type viruses.Hi Patti- I'm pretty sure most viruses can be detected by PCR with a blood test (ie. ebv, cmv, etc.)
Jim
It is actually very unusual to be PCR positive to herpes type viruses.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5267872/Introduction
In most developing countries, Cytomegalovirus (CMV), Epstein Barr virus (EBV) and Herpes virus 6 (HHV-6) are not diagnosed in blood donors. The aim of this study is to determine the prevalence of these viruses in blood donors from the city of Ouagadougou, Burkina Faso.
Methods
The study included 198 blood donors of the Regional Blood Transfusion Centre of Ouagadougou. Multiplex real time PCR was used to diagnose the three viruses. Statistical analysis was performed with the software EpiInfo version 6 and SPSS version 17. P values ≤ 0.05 were considered significant.
Results
Of 198 samples tested, 18 (9.1%) were positive to at least one of the three viruses. In fact, 10 (5.1%) were positive for EBV, 10 (5.1%) positive for CMV and 12 (6.1%) positive for HHV-6. Viral infections were higher in women than in men, EBV (8,6% versus 4.3%), CMV (8.6% versus 3.7%) and HHV-6 (11.4% versus 4.9%). EBV / CMV / HHV-6 co-infection was found in 3.5% (7/198) of blood donors.
The inhibition of methylation reactions in the cell also affects neurotransmitter (dopamine, norepinephrine, and serotonin) and phosphatidylcholine membrane lipid synthesis, folate and B12 metabolism, and many other reactions. So by giving antivirals, doctors are not just inhibiting viruses, they are also inhibiting many host cell metabolic functions.
This chart talks about different testing methodologies and whether they can or can't determine active from latent infection for HHV-6. I have always assumed that the same would hold true for EBV. But i don't really know the difference between these tests, and the Multiplex PCR from your linked article.Hi Ema-Wouldn't a negative PCR test mean the virus is latent and not active? Assuming one has the infection.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5267872/
Jim
Of 198 samples tested, 18 (9.1%) were positive to at least one of the three viruses. In fact, 10 (5.1%) were positive for EBV, 10 (5.1%) positive for CMV and 12 (6.1%) positive for HHV-6. Viral infections were higher in women than in men, EBV (8,6% versus 4.3%), CMV (8.6% versus 3.7%) and HHV-6 (11.4% versus 4.9%).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5267872/
Ask me after another thirty years of science is done.Coincidence?