Scientists catch the rogue molecule that can trigger autoimmunity

[AdamS]

Wow...looks interesting and quite relevant to us. Thoughts? Seems that if damaged, mitos can wreak havoc and drive inflammation via immune response etc. I wonder if this mtDNA being outside the mitochondria is one of the antigens/molecular mimics Mark Davis & co are looking for.

Article: https://medicalxpress.com/news/2018-02-dna-scientists-rogue-molecule-trigger.html

Paper: http://science.sciencemag.org/content/359/6378/eaao6047

 

[Learner1]

I wonder, too... Thanks for posting.

 

[Learner1]

I found this, which seems to say environmental toxins can cause release of mtDNA into serum.

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0064413

The relative amounts of mtDNA-79 in serum were positively associated with the lag-time after intoxication to these chemicals.

Our findings indicate that mitochondrial DNA has a potential to serve as a biomarker recognizing vulnerable risk groups after exposure to toxic/carcinogenic chemicals.

 

[AdamS]

I found this, which seems to say environmental toxins can cause release of mtDNA into serum.

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0064413

Good find! Interesting stuff.