bertiedog
Senior Member
- Messages
- 1,738
- Location
- South East England, UK
I have recently had the results of my Genova Organic Comprehensive Profile which was done on the first void of the morning. Some of the results of very worrying and show high oxidative stress, very poor detoxification with very little evidence of glutathione, urea cycle overload (ammonia toxicity), intestinal bacterial overgrowth which I already knew about, plus yeast overgrowth. There was also a marker for Clostridia overgrowth and that was high too. I have been working on changing the bacteria in my gut but only since September so obviously a huge way to go.
The other result which was interesting was pyruvate was not detected although the fatty acid metabolism was fine. Genova say that pyruvate is a marker for carbohydrate mechanism and show evidence of ketosis. I do eat a lowish carb diet but always have a small snack at 10 pm with a bit of carb and fat to get me through the night. I guess it also explains why my blood sugar is pretty low on waking and I think this is what triggers the headaches/migraines when I do eat plus all the toxicity.
There are some markers in the Citric Acid Cycle which are too high, mainly to do with B vits, especially B12 and folate. I already knew about those but I have been unable to take the methylated form of vitamins because they have given me daily migraines in the past. I have SNPs which mean I don't tolerate methyl groups well so I seem to be between and rock and a hard place.
To try and tolerate at least some folate and B12 I have had to start a migraine preventative drug and I think it is helping at the moment so possibly I might be able to improve some of the markers. I seem to be tolerating around 400 - 500 mg methyfolate plus the last few days I have been ok on 2500 B12 which is a mixture of AdenB12/Methyl B12 and HydroxyB12. I have asked Dr M if she can help me sort some of this out because I think I will need some medication for the bacterial overgrowth and also anti fungal meds because herbals haven't worked for me, probably cos there is just too much going on.
I have to say a lot of the stuff that has been highlighted isn't actually off their chart, just towards the high end so I try and console myself with that fact at least! I should say that I am 70 in a few month's time so I have had a lifetime of building up this rubbish and I am pretty positive that the SNPs I have got are a lot to do with the issues I have.
Pam
The other result which was interesting was pyruvate was not detected although the fatty acid metabolism was fine. Genova say that pyruvate is a marker for carbohydrate mechanism and show evidence of ketosis. I do eat a lowish carb diet but always have a small snack at 10 pm with a bit of carb and fat to get me through the night. I guess it also explains why my blood sugar is pretty low on waking and I think this is what triggers the headaches/migraines when I do eat plus all the toxicity.
There are some markers in the Citric Acid Cycle which are too high, mainly to do with B vits, especially B12 and folate. I already knew about those but I have been unable to take the methylated form of vitamins because they have given me daily migraines in the past. I have SNPs which mean I don't tolerate methyl groups well so I seem to be between and rock and a hard place.
To try and tolerate at least some folate and B12 I have had to start a migraine preventative drug and I think it is helping at the moment so possibly I might be able to improve some of the markers. I seem to be tolerating around 400 - 500 mg methyfolate plus the last few days I have been ok on 2500 B12 which is a mixture of AdenB12/Methyl B12 and HydroxyB12. I have asked Dr M if she can help me sort some of this out because I think I will need some medication for the bacterial overgrowth and also anti fungal meds because herbals haven't worked for me, probably cos there is just too much going on.
I have to say a lot of the stuff that has been highlighted isn't actually off their chart, just towards the high end so I try and console myself with that fact at least! I should say that I am 70 in a few month's time so I have had a lifetime of building up this rubbish and I am pretty positive that the SNPs I have got are a lot to do with the issues I have.
Pam