notmyself
Senior Member
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any glimpse of hope ? is the research moving in the right direction?..i can't find anything on the web, except ussual bulshit,but maybe i don t know where to look..does something notable happen latelly? 
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any new exciting research?
- Thread starter notmyself
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ivorin
Senior Member
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- 152
This one's somewhat big: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0186802any glimpse of hope ? is the research moving in the right direction?..i can't find anything on the web, except ussual bulshit,but maybe i don t know where to look..does something notable happen latelly?
Cellular bioenergetics is impaired in patients with chronic fatigue syndrome
helperofearth123
Senior Member
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- 202
What does this mean? There was another study that I thought showed that the problem was in the blood not the mitochondria after all and now this one is pointing out mitochondria again. Is the type of cell they are looking at being a blood cell of any significance?
ivorin
Senior Member
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- 152
That's the right question. They haven't tested the cells inside the serum, nor have they tested cells other than blood cells. They intend to follow-up with a larger scale study that should look into muscle cells, then we will know more of how this correlates with Davis' "something in the serum".
They were looking at PBMCs (peripheral blood mononuclear cells). Mitochondria are mentioned because Oxidative phosphorylation usually takes place inside them, this study seemed to find/validate that there are issues with the OXPHOS pathway in ME/CFS patients which could explain why our cells fail to meet energetic demands.
From Wiki:
A peripheral blood mononuclear cell (PBMC) is any peripheral blood cell having a round nucleus. These cells consist of lymphocytes (T cells, B cells, NK cells) and monocytes, whereas erythrocytes and platelets have no nuclei, and granulocytes (neutrophils, basophils, and eosinophils) have multi-lobed nuclei.
Edit: Agreed though, this study doesn't really uncover WHY the OXPHOS pathway is broken.
It also doesn't prove that the mitochondrial dysfunction is part of the cause of ME/CFS, or just a side effect. My poll about stamina in the PEM/Fatigue forum so far shows that I'm unique in not suffering from reduced stamina, but that still doesn't answer the question of whether the mito dysfunction is cause or effect.