Tate Mitchell to CO-CURE May 8
'Exercise Tolerance Testing in a Prospective Cohort of Adolescents
with Chronic Fatigue Syndrome and Recovered Controls Following
Infectious Mononucleosis'
Katz BZ, Boas S, Shiraishi Y, Mears CJ, Taylor R.
J Pediatr. 2010 May 5. [Epub ahead of print]
Department of Pediatrics, Northwestern University, Feinberg School of
Medicine and Children's Memorial Hospital, Chicago, IL.
http://www.ncbi.nlm.nih.gov/pubmed/20447647
Abstract
OBJECTIVE: Six months after acute infectious mononucleosis (IM), 13%
of adolescents meet criteria for chronic fatigue syndrome (CFS). We
measured exercise tolerance in adolescents with CFS and control
subjects 6 months after IM.
STUDY DESIGN: Twenty-one adolescents with CFS 6 months after IM and 21
recovered control subjects performed a maximal incremental exercise
tolerance test with breath-by-breath gas analysis. Values expressed
are mean +/- standard deviation.
RESULTS: The adolescents diagnosed with CFS and control subjects did
not differ in age, weight, body mass index, or peak work capacity.
Lower oxygen consumption peak percent of predicted was seen in
adolescents with CFS compared with control subjects (CFS 99.3 +/- 16.6
vs control subject 110.7 +/- 19.9, P = .05). Peak oxygen pulse also
was lower in adolescents with CFS compared with recovered control
subjects (CFS 12.4 +/- 2.9 vs control subjects 14.9 +/- 4.3, P = .03).
CONCLUSIONS: Adolescents with CFS 6 months after IM have a lower
degree of fitness and efficiency of exercise than recovered
adolescents. Whether these abnormal exercise findings are a cause or
effect of CFS is unknown. IM can lead to both fatigue and measurable
changes in exercise testing in a subset of adolescents.
Copyright 2010 Mosby, Inc. All rights reserved.
'Exercise Tolerance Testing in a Prospective Cohort of Adolescents
with Chronic Fatigue Syndrome and Recovered Controls Following
Infectious Mononucleosis'
Katz BZ, Boas S, Shiraishi Y, Mears CJ, Taylor R.
J Pediatr. 2010 May 5. [Epub ahead of print]
Department of Pediatrics, Northwestern University, Feinberg School of
Medicine and Children's Memorial Hospital, Chicago, IL.
http://www.ncbi.nlm.nih.gov/pubmed/20447647
Abstract
OBJECTIVE: Six months after acute infectious mononucleosis (IM), 13%
of adolescents meet criteria for chronic fatigue syndrome (CFS). We
measured exercise tolerance in adolescents with CFS and control
subjects 6 months after IM.
STUDY DESIGN: Twenty-one adolescents with CFS 6 months after IM and 21
recovered control subjects performed a maximal incremental exercise
tolerance test with breath-by-breath gas analysis. Values expressed
are mean +/- standard deviation.
RESULTS: The adolescents diagnosed with CFS and control subjects did
not differ in age, weight, body mass index, or peak work capacity.
Lower oxygen consumption peak percent of predicted was seen in
adolescents with CFS compared with control subjects (CFS 99.3 +/- 16.6
vs control subject 110.7 +/- 19.9, P = .05). Peak oxygen pulse also
was lower in adolescents with CFS compared with recovered control
subjects (CFS 12.4 +/- 2.9 vs control subjects 14.9 +/- 4.3, P = .03).
CONCLUSIONS: Adolescents with CFS 6 months after IM have a lower
degree of fitness and efficiency of exercise than recovered
adolescents. Whether these abnormal exercise findings are a cause or
effect of CFS is unknown. IM can lead to both fatigue and measurable
changes in exercise testing in a subset of adolescents.
Copyright 2010 Mosby, Inc. All rights reserved.