Posting again here as there is a duplicate thread...
IMO I don't think Lipkin's work is that compelling and I do not believe they will find much of anything that is actionable. The Microbe Discovery Project is interesting work from a research perspective but I highly doubt it will lead to absolutely anything actionable.
What important work has Lipkin published on ME/CFS in the last 5 or more years? Really nothing other than the cytokine work. Hornig and Lipkin's paper on cytokines was interesting but only somewhat validated what we already knew, nothing new and nothing that we could do anything with. Just like with the cytokine study, searching in our microbiome for abnormalities will not really lead to any treatment, it will just be somewhat interesting research to gain some knowledge and that's that.
I believe only two groups, Fluge/Mella and Davis/Naviaux, are looking directly at what is causing the key debilitating symptoms of this disease and have hypotheses that will lead to actionable knowledge and treatments within the next 5 years. It's a total shame that they didn't get funded by NIH and Lipkin did.