It is my understanding that over time increased output of cortisol (stressors like pain, being sick, emotions e.g. loneliness, PTSD etc) might contribute to many of these problems related to orthostatic intolerance (blood pressure regulation, vasodilation), low blood sugar issues (waking up 04 with heartbeat and high pulse), thyroid down regulation (switch to reverse T3 over T3 production), anxiety (fight & flight, sympathic nervous system activation), lower back pain/tension/anxiety, adrenal hormone depletion (cortisol grabs most of the pregnenolone and less goes to DHEA, dopamin, testosteron etc, hence rendering you with increased risk of tissue damage, depression, low libido aso).
Relora, tyrosine, theanine, vit C, phosphatidyl serine, GABA, pregnenolone, adaptogens - might contribute to balancing the adrenals and reducing cortisol - as will any lifestyle interventions that reduce stress (walks & movement, yoga, meditation, nature, connection, blue-blocking, sleep aso).
Any earlier trauma - childhood, losses, PTSD, injuries - might be sources of excess cortisol also (amygdala, the fear centre (?)).
PS! I used ZRT labs to measure adrenal hormones. Will also try to have my DHEA and cortisol tested during the course of one day (spit test, 4 times).