P5p good response

[jump44]

So I had ordered a bunch of sublingual b vitamins from Swanson awhile back since taking a b complex gives me weird results to say the least. Anyways I've been taking fad b2 for awhile on and off with ok results, nothing too helpful. Also I take methylation supps a few times a week.(folate, methylb12 in a nasal spray, tmg.)

I had held off on taking the p5p because I kept reading people on here having generally bad results with it. Anyways a few weeks ago I decided to split open a 25 mg cap and take half. Immediately I sensed a nice feeling of calmness and I sleptt good that night with some very intense dreams. I've been taking about 10mg every other day for 2 weeks and it's reliably given me a good nights sleep and the next day has been better than my norm.

I'm just wondering what this could indicate. I also am on ldn, immunovir, a nasal spray that has b12,nicotinakide riboside and ginseng, and also nasal glutathione. These things have all helped in their own way but the p5p seemed to "open up" another layer of my brain(best way I can explain it). My diet includes a lot of foods that are supposedly high in b6 so I'm a bit stumped on this. I'm happy for any improvement but as I've learned with cfs , things can backfire so I'm going slowly with it. I just thought I'd share.

 

[drob31]

p5p aka active b6 is probably increasing BH4 which is converting more tyrosine to L-DOPA which then turns to dopamine.

 

[Mary]

I like p5p a lot. In 2010 I had Nutreval testing done which showed a severe B6 deficiency, although I didn't find this out until 3 years ago I think. Why this deficiency, I have no idea. I'd been taking a B complex forever. Anyways, I added in p5p and had a noticeable increase in energy. I've been taking 50 mg. ever since.

One of my sisters, who does not have ME/CFS, did have symptoms of pyroluria apparently related to a B6 deficiency. Though she used to get very tan as a child (my family vacillates between very fair to very easily tanning), in recent years she stayed pale, with a pallor, unable to get any color in her skin despite being in the sun. She also had some other symptoms of pyroluria. I recommended she start taking P5P, and just this year I noticed she was getting some color again, which she was very happy to see. So I'm thinking there may be a genetic component in my family.

 

[drob31]

I like p5p a lot. In 2010 I had Nutreval testing done which showed a severe B6 deficiency, although I didn't find this out until 3 years ago I think. Why this deficiency, I have no idea. I'd been taking a B complex forever. Anyways, I added in p5p and had a noticeable increase in energy. I've been taking 50 mg. ever since.

One of my sisters, who does not have ME/CFS, did have symptoms of pyroluria apparently related to a B6 deficiency. Though she used to get very tan as a child (my family vacillates between very fair to very easily tanning), in recent years she stayed pale, with a pallor, unable to get any color in her skin despite being in the sun. She also had some other symptoms of pyroluria. I recommended she start taking P5P, and just this year I noticed she was getting some color again, which she was very happy to see. So I'm thinking there may be a genetic component in my family.

I still can't figure out if pyroluria is a legit diagnosis or not. I was "borderline." But it also says you can be deficient in zinc, and zinc seems to have a bad effect on me, no matter what form I try, unless it's herxing me or something.

 

[Mary]

I still can't figure out if pyroluria is a legit diagnosis or not. I was "borderline." But it also says you can be deficient in zinc, and zinc seems to have a bad effect on me, no matter what form I try, unless it's herxing me or something.

I don't know what to tell you. My sister was not officially diagnosed by anyone, it's just she matched most of the symptoms I read about, and, seeing how deficient I was in B6 from the Nutreval testing and my positive response to it, I figured it was very likely my sister was deficient too, though not as bad as me. I've been taking zinc with no problem for a long time. Maybe the zinc causes a deficiency in something else, which is why you react badly to it - it can get so complicated, everything is inter-related!

Gondwanaland seems to be very knowledgeable in many areas of nutrition, you might try asking her about zinc and your reaction to it.

 

[Critterina]

My opinion is that there is probably a genetic (probably unidentified as of yet) reason that some of us still show B6 functional deficiency even with foods high in B6 and with supplementation.

My story, as I've told it in other threads: I took 100 mg pyridoxine hydrochloride per day for several months, having been diagnosed by an acupuncturist on the basis of observation, before having lab tests. The tests showed I was still functionally deficient. Having become familiar with the folic acid/methylfolate experience of others, I tried P5P instead of P-HCl, thinking there may be a similar "activation mechanism" problem. My lab tests no longer showed deficiency, with only 50 mg P5P.

I would be interested in any research on this, as I would like to understand it for myself. And it would also be useful to predict who else might be helped by the active form of this vitamin.

 

[drob31]

My opinion is that there is probably a genetic (probably unidentified as of yet) reason that some of us still show B6 functional deficiency even with foods high in B6 and with supplementation.

My story, as I've told it in other threads: I took 100 mg pyridoxine hydrochloride per day for several months, having been diagnosed by an acupuncturist on the basis of observation, before having lab tests. The tests showed I was still functionally deficient. Having become familiar with the folic acid/methylfolate experience of others, I tried P5P instead of P-HCl, thinking there may be a similar "activation mechanism" problem. My lab tests no longer showed deficiency, with only 50 mg P5P.

I would be interested in any research on this, as I would like to understand it for myself. And it would also be useful to predict who else might be helped by the active form of this vitamin.

How do you test for a functional deficiency versus a blood level deficiency?

 

[NotThisGuy]

p5p aka active b6 is probably increasing BH4 which is converting more tyrosine to L-DOPA which then turns to dopamine.

Interesting. Any further information on this? (source or something)

 

[Alvin2]

p5p aka active b6 is probably increasing BH4 which is converting more tyrosine to L-DOPA which then turns to dopamine.

Then treatment would be as simple as sinemet (levodopa + carbidopa, a Parkinsons medication)

 

[Chans]

I still can't figure out if pyroluria is a legit diagnosis or not. I was "borderline." But it also says you can be deficient in zinc, and zinc seems to have a bad effect on me, no matter what form I try, unless it's herxing me or something.

Pyroluria most definitely can be a legitimate diagnosis; in the worst cases it causes psychotic episodes that respond well and rapidly to zinc and b6. Now, whether borderline cases are is another question...

 

[Critterina]

How do you test for a functional deficiency versus a blood level deficiency?

An serum amino acid panel will show you levels of amino acids in your blood. Then, based on what amino acids are low or elevated, you can deduce what functionality is missing. At least to some extent. Because things overlap in influencing things, it really helps to have a specialist to help. Metametrix and Genova have posted Amino Acid Interpretive Guides. I'm attaching what I have - not necessarily current, but if you find a current one, please post it.