Hi everyone
I'm dead tired and feel awful...
Can someone interpret what exactly they mean with histamine receptor 3 and the human heart. I know they talk about proteins and calcium channels as well...but..
Bottomline for me is following:
What stimulates the heart MORE
histamine H3 antagonist or agonist ?
Quote from:
https://www.ncbi.nlm.nih.gov/pubmed/7788879
http://circres.ahajournals.org/content/77/1/206
I know antagonist effect at h3 results in more neurotransmitters being used/allocated...
Like acetylcholine, dopamine, noradrenaline, serotonin, gaba
Therefor it would be logical to me that an antagonist would stimulate the heart more...
and that an agonist effect would decrease heart rate = less stimulation.
I'm on to something here that can literally save me...I just need another confirmation...
Thanks for your help
I'm dead tired and feel awful...
Can someone interpret what exactly they mean with histamine receptor 3 and the human heart. I know they talk about proteins and calcium channels as well...but..
Bottomline for me is following:
What stimulates the heart MORE
histamine H3 antagonist or agonist ?
Our findings are the first demonstration that H3-receptors are present in sympathetic nerve endings in the human heart, where they modulate adrenergic responses by inhibiting norepinephrine release.
Quote from:
https://www.ncbi.nlm.nih.gov/pubmed/7788879
http://circres.ahajournals.org/content/77/1/206
I know antagonist effect at h3 results in more neurotransmitters being used/allocated...
Like acetylcholine, dopamine, noradrenaline, serotonin, gaba
Therefor it would be logical to me that an antagonist would stimulate the heart more...
and that an agonist effect would decrease heart rate = less stimulation.
I'm on to something here that can literally save me...I just need another confirmation...
Thanks for your help