@Helen
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The GST SNP is interesting. It appears I have the following via LiveWellO report. What does this mean?
GSTM1 rs1056806 T CC -/-
GSTM1 rs2239892 G __ NG
GSTM1 rs4147565 A -- NC
GSTM1 rs4147567 G __ NG
GSTP1 rs1138272 T CT +/-
GSTP1 rs1695 G AG +/-
GSTM3 rs7483 T CC -/-
GSTP1 [ +/- ]
Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases. [provided by RefSeq, Jul 2008]
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I have a different Gene SNP interpretation report that shows:
GSTM1 (rs1056806) CC 87.8%
GSTP1 A114V (rs1138272) 1 CT 14.6%
GSTP1 I105V (rs1695) 1 AG 44.0%
GSTs Total 85%
GSTA1 88%
GSTA2 80%
GSTA3 90%
GSTA4 79%
GSTA5 100%
GSTK1 100%
GSTM1 91%
GSTM2 80%
GSTM3 83%
GSTM4 93%
GSTM5 83%
GSTO1 100%
GSTO2 75%
GSTP1 85%
GSTT1 100%
GSTZ1 43%
GSTs include the following classes:
A- (alpha-), P- (pi-), M- (mu-), O- (omega), T- (theta), and Z - (Zeta) These genes encode enzymes that add glutathione to target electrophilic compounds such as therapeutic drugs, environmental toxins, and products of oxidative stress. This action is an important step in detoxification of these compounds. All the GST SNPs can be found in the Gene Report. The eznymes GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO1, GSTO2, GSTP1, GSTT1, and GSTZ1 can all be found in the Enzyme Report.
GSTA2 (rs1803682) CC 100.0%
GSTA2 (rs60332313) TT 99.9%
GSTA2 (rs2234951) GG 92.8%
GSTA2 (rs142078893) CC 100.0%
GSTA2 (rs2608632) 2 TT 8.8%
The enzyme encoded by GSTA2 plays a role in the detoxification of electrophilic compounds, including environmental toxins, and products of oxidative stress, by conjugation with glutathione. Variations in this gene can change an individual's susceptibility to toxins. The enzyme encoded by GSTA2 also exhibits glutathione peroxidase activity and thereby protects the cells from reactive oxygen species and the products of peroxidation.
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