rs956572AA - Inositol and Bipolar

[Peyt]

Hi,
Does anyone know if this gene rs956572AA is responsible for bipolar disorder?
I have the (A,G) version and as soon as when I take Inositol the first day I get a real nice Euphoric feeling and then starting the second day I get manic and then crash with sever headache.... wondering if it's from this gene and if yes is there any solutions for it? I know I can just not take Inositol, but I get this up and down feeling all the time anyways and Inositol just makes it worst so I would love to find a solution for it if possible. Any thoughts are appreciated.

 

[alicec]

Does anyone know if this gene rs956572AA is responsible for bipolar disorder?

The short answer is no, neither that SNP nor the gene in which it occurs (BCL2), is responsible for the disorder.

Twin studies do show that there is a strong heritability component to the disorder, though interestingly in practice this is not so clear. Most cases are isolated.

Large scale genome wide association studies have shown a robust link to several genes (though not BCL2) but the contribution of any one gene is small. They are risk factors, not causes. Furthermore there is a clear environmental component to onset of the disorder.

Here and here are a couple of recent reviews.

 

[Peyt]

How about this report: http://www.sciencedirect.com/science/article/pii/S0006322310011121

 

[Valentijn]

How about this report: http://www.sciencedirect.com/science/article/pii/S0006322310011121

It's a tiny study, in a pretty abnormal group. They also don't say anything about the effect size in the abstract, which is a bit of a warning sign, so it's probably a very small effect, if there actually is an effect.

To answer your earlier question, this study says absolutely nothing about the SNP being associated with causing bipolar disorder. There's no suggestion that it's causative, though perhaps the paper cites to another paper which does suggest that.

 

[Peyt]

Interesting,
This paper suggests that the reason Lithium works on Bipolar is because it inhibits the action of inositol... Would this indirectly suggest that inositol could cause bipolar?
http://www.nature.com/mp/journal/v10/n1/full/4001618a.html

 

[alicec]

Interesting,
This paper suggests that the reason Lithium works on Bipolar is because it inhibits the action of inositol... Would this indirectly suggest that inositol could cause bipolar?
http://www.nature.com/mp/journal/v10/n1/full/4001618a.html

No, it suggests that the second messenger system initiated by inositol tri-phosphate MIGHT play some role in the action of mood stabilising drugs such as lithium.

As the review you cite says

Finally, it is often assumed that mood stabilizers target the causes of the disorder, but this does not have to be the case. Mood stabilizer therapy could cause neural changes in bipolar disorder patients, such as depressed signaling, increased cell survival or altered neuronal connectivity, which make compensatory changes rather than reverse the original biological lesion. In this case, the biochemical basis of the bipolar disorder therapy may be completely different from that of its origins.