Hey Grapes, I was thinking that maybe the increased heart rate you experienced could be linked to excess glutamate. I've read in several places that many of us have high glutamate and it seems (on wiki) that folate has glutamate in its chemical make-up. I also read that resveratrol increases glutamate uptake so gets rid of it:
https://scholar.google.co.uk/scholar?q=resveratrol, glutamate uptake&btnG=&hl=en&as_sdt=0,5&sciodt=0,5&cites=13411763533213580982&scipsc=
As I said before that I wondered if me running out of resveratrol had made the difference between the one month of feeling great on the Simplified methylation protocol and the downright yukky, foggy, anxious feelings I got after that which led me to stop my methylation supps for about a week. During that time, I ordered more resveratrol and (also lithium because I read that helped with glutamate excitotoxicity but it made me too stupid!) and started back on 1,400 mcg Methyl Folate and 4000mcg Methyl B12, AND 250mg Swanson resveratrol and had no anxiety or foggy feelings since.
I also read somewhere that glutamate is a bladder stimulant and serotonin does the opposite and since I started the SMP, I no longer have to get out of bed at 1am every night without fail to pee, even if I stopped all fluids by 7pm! Now I don't need to go until 5-6am (small victory but it makes me feel like positive changes are occurring). I can't recall if this was different when I ran out of resveratrol though so not sure if its that making the difference or improvements to methylation in general.
I am pleased to say I have been feeling 9/10 every day for the last couple of weeks, although I overdid it the day before yesterday - I was on the go from 6am til 11pm due to a job interview and a late turn at work, so I am suffering with PEM, whole body aching, right now and have had to resort to 800mg of ibuprofen.
Before trying the SMP I was feeling 7 or 8/10 on good days but only had one good day a fortnight and the rest I was feeling bad (although rarely housebound).
I think I should also say, that I take 150mg of tramadol every day which alleviates some of the fluey ME symptoms in me. I originally got the tramadol from the doctor for back pain but it a side-effect is that it helps my fatigue!