aimossy
Senior Member
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- 1,106
So I'm afraid I'm back to wanting to see an example of gut microbiota imbalance causing disease.
C Difficile.
You are aware there isn't anything solid in this area, which is why you stated this
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So I'm afraid I'm back to wanting to see an example of gut microbiota imbalance causing disease.
C Difficile. You are aware there isn't anything solid in this area, which is why you stated this
Which makes me wonder even more - what's the point of this research?
But their own results suggest there's no evidence of elevated cytokines.
Done.Why not try to look for a connection between microbiota composition and levels of LPS in the plasma?
he (Lipkin) is in direct competition with the likes of Ron Davis who has managed to capture the community's imagination more effectively
This is very Real and very Powerful IMO.
C Difficile.
You are aware there isn't anything solid in this area, which is why you stated this
Clostridium difficile is a Gram positive, spore forming anaerobic bacillus that in contrast with popular belief is not a normal commensal of the adult gastrointestinal tract.1 The organism is acquired from an exogenous source and given certain conditions can induce disease.
´Independent of IBS, ME/CFS is associated with dysbiosis and distinct bacterial metabolic disturbances that may influence disease severity.´
Question: do you care how severe your disease is?
I really doubt if it's teoretically possible to kill, like, all of a bacterial population. I would guess that regardless of method, there will allways remain a rest population.When trying to kill off specific bacteria the only strategy I am aware of is to kill them all and repopulate. Is anyone aware of other scientifically established protocols?
Just wait for someone to test LPS and cytokine levels in people with ME after exercise. I believe we will see a much stronger correlation, with a greater separation between cases and controls.
Well.. like 25 years ago, I did understand some of what was then known about endothelial cells (and immune system cells).probably you understand it better than me but in my mind, the LPS are being produced, and it is an unrelated failure of the microbial ecology that provides the increased intenstinal permeability, rather than the LPS being so many that they force their way through.
when will finally banish that horrible term and put it just in history books?Article in The Times: https://www.thetimes.co.uk/article/gut-bacteria-linked-to-chronic-fatigue-30wkq5fjp (behind Paywall)
Couldn't prevent themselves from refering to "Yuppie flu":
And link to the paper: http://download.springer.com/static/pdf/226/art%3A10.1186%2Fs40168-017-0261-y.pdf?originUrl=http://microbiomejournal.biomedcentral.com/article/10.1186/s40168-017-0261-y&token2=exp=1493193593~acl=/static/pdf/226/art%253A10.1186%252Fs40168-017-0261-y.pdf*~hmac=b1dd5b21d6253c71b9741fb5e8044a6194276c6f84b19b58b950f092764bb353
I think the underlying cause-s of an altered microbiome in PWME has to be treated first. I assume a faecal transplant wouldn´t be a cure otherwise. I think it has been tried already with a temporary, good effect.we need faecal transplant urgently... as soon as I can do it, I'll do it! I need a healthy gut microbiome right now!
The issue really is to see why these "nasty bugs" are where they are....
I know at least one PWME who was made significantly worse from it and has had terrible gastro issues ever since, far worse than the original issue. We should be careful.I think the underlying cause-s of an altered microbiome in PWME has to be treated first. I assume a faecal transplant wouldn´t be a cure otherwise. I think it has been tried already with a temporary, good effect.