Monash University researchers have discovered the mechanism underlying the fainting disorder, POTs

[Seven7]

The CCS scientists discovered chemical marks on the NET gene responsible for repressing or turning the gene off. They delved further and found that a repressor protein called MeCP2 together with a non-coding RNA (let-7i) was critical in the gene silencing.
In another exciting development, the researchers, collaborating with the Baker Institute’s Professor Murray Esler, demonstrated that the NET gene could be re-activated by using the FDA approved drug Vorinostat in blood cells derived from POTS study participants.

http://neurosciencenews.com/fainting-disorder-neurology-6293/

 

[Seven7]

Another chemo drug?!!!
If we have so much cross over with cfs, our issue has to be in the same neighborhood!

 

[Hugo]

The CCS scientists discovered chemical marks on the NET gene responsible for repressing or turning the gene off. They delved further and found that a repressor protein called MeCP2 together with a non-coding RNA (let-7i) was critical in the gene silencing.
In another exciting development, the researchers, collaborating with the Baker Institute’s Professor Murray Esler, demonstrated that the NET gene could be re-activated by using the FDA approved drug Vorinostat in blood cells derived from POTS study participants.

http://neurosciencenews.com/fainting-disorder-neurology-6293/

Thats huge. Very important research.

 

[Hugo]

Vorinostat seems like an interesting medicine. Could be a better HIV treatment in the relative near future http://www.sciencealert.com/a-new-hiv-treatment-could-have-cured-a-patient-in-britain

 

[BurnA]

Did You See they have Depression as a keyword under the article, and as for "Wiggles disease", hmmm.

Still, positive news, can we believe it?

 

[Hugo]

Did You See they have Depression as a keyword under the article, and as for "Wiggles disease", hmmm.

Still, positive news, can we believe it?

I didnt see anything in the article about depression though so it may be irrelevant.

No I see it now, I missed it in the article..it was for a possible future use of the drug and possibly use of the knowledge about the MeCP2 and RNA (let-7i). Dont really know why they think its suppose to help in depression and panic dissorder but maybe its because its norepinephrine transporter gene.

 

[Seven7]

The Wiggle is a kids' singers group! One of the singers have POTs why the Wiggles tag!

 

[BruceInOz]

The Wiggle is a kids' singers group! One of the singers have POTs why the Wiggles tag!

And The Wiggles are Australian and Monash University (the source of the science mentioned) is Australian. You get a lot more understanding here in Oz if you say "what forced the Yellow Wiggle to quit" than "POTS".