Methylation has been a huge struggle for me for more than 2 years now.
I've tried taking methylfolate several times, but something goes horribly wrong. Not immediately, but very slowly I start to feel worse. Until I'm almost completely bedridden, totally exhausted, like all strength and energy is sucked out of me (which also affects my brains, it's really hard to think clearly).
It takes a couple of weeks after I start with folate before it gets this bad. And it takes even longer after I stop taking folate before I get some strength back.
I have no problems taking b12. Before I did the 23andme test I took lozenges of 500mcg L-methylfolate and 1500mcg b12 (adeno+methyl) for a few months, which caused the first massive setback in my health.
I stopped taking those tablets and started with both forms of b12 10mg twice a day. It took a few weeks, but the change was remarkable. I felt better than I had in years! (A few years earlier I was diagnosed and treated for Lyme).
That changed when my doctor advised me to slowly add folate again (from 100 to 800mcg). This was Sept 2015 and I haven't felt that good ever since.
Last January I tried folate for the fifth time, with only 50-75mcg every other day. The results are just as bad, apparently I don't tolerate any folate.
I've tried potassium, Niacin and other b vitamins, different kinds of folate (Quetrefolic and L-methylfolate), but nothing changed.
My doctor has no idea what causes my extreme reaction to folate.
I've searched a LOT but haven't found anything useful so far.
Anyone who knows what the problem might be? Any advice would be greatly appreciated!
My SNPs:
Homozygous AGT, GAD1, MTHFR C677T, MTRR, PEMT, SOD3, TCN2 (MAO A R297R, VDR Taq, ITGB3, CYP1B1, CYP2C9, NAT2, IFIH1, IRF5, TRAF1, C3, FCGR2A, NDUFS7, SLC19A1, HLA-DRB1)
Heterozygous BHMT, BHMT-02, BHMT-08, CBS, CBS A360A, COMT H62H, COMT V158M, DAO, DHFR, FOLR2, GIF, MTHFD1, MTHFD1L, MTRR A664A, NOS2 NOS3, SOD2 (C11orf30, HLA-DQB1, IRF6, PVT1, CYP4V2, F10 F11 F12, CYP1A2, CYP1B1, GSTP1, NAT2, IGF1R, PSMB8, CD14, FCER1A, IL5, RAD50, RAG1, CCL2, COX5A, COX6C, APOE, ATG16L1, IL4R)
I've tried taking methylfolate several times, but something goes horribly wrong. Not immediately, but very slowly I start to feel worse. Until I'm almost completely bedridden, totally exhausted, like all strength and energy is sucked out of me (which also affects my brains, it's really hard to think clearly).
It takes a couple of weeks after I start with folate before it gets this bad. And it takes even longer after I stop taking folate before I get some strength back.
I have no problems taking b12. Before I did the 23andme test I took lozenges of 500mcg L-methylfolate and 1500mcg b12 (adeno+methyl) for a few months, which caused the first massive setback in my health.
I stopped taking those tablets and started with both forms of b12 10mg twice a day. It took a few weeks, but the change was remarkable. I felt better than I had in years! (A few years earlier I was diagnosed and treated for Lyme).
That changed when my doctor advised me to slowly add folate again (from 100 to 800mcg). This was Sept 2015 and I haven't felt that good ever since.
Last January I tried folate for the fifth time, with only 50-75mcg every other day. The results are just as bad, apparently I don't tolerate any folate.
I've tried potassium, Niacin and other b vitamins, different kinds of folate (Quetrefolic and L-methylfolate), but nothing changed.
My doctor has no idea what causes my extreme reaction to folate.
I've searched a LOT but haven't found anything useful so far.
Anyone who knows what the problem might be? Any advice would be greatly appreciated!
My SNPs:
Homozygous AGT, GAD1, MTHFR C677T, MTRR, PEMT, SOD3, TCN2 (MAO A R297R, VDR Taq, ITGB3, CYP1B1, CYP2C9, NAT2, IFIH1, IRF5, TRAF1, C3, FCGR2A, NDUFS7, SLC19A1, HLA-DRB1)
Heterozygous BHMT, BHMT-02, BHMT-08, CBS, CBS A360A, COMT H62H, COMT V158M, DAO, DHFR, FOLR2, GIF, MTHFD1, MTHFD1L, MTRR A664A, NOS2 NOS3, SOD2 (C11orf30, HLA-DQB1, IRF6, PVT1, CYP4V2, F10 F11 F12, CYP1A2, CYP1B1, GSTP1, NAT2, IGF1R, PSMB8, CD14, FCER1A, IL5, RAD50, RAG1, CCL2, COX5A, COX6C, APOE, ATG16L1, IL4R)