WoolPippi
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CYP2C19*17 is a liver enzym that busies itself with things like blood thinners and hormones. I'm homozygous for it which makes me an ultrafast metabolizer. Here's SNPedia about how that's classified
Ultrafast means my enzym metabolizes all its substrates superfast. Progesteron is such a substrate and CYP2C19*17 grabs it all from the blood and destroys it. I need to take MUCH MORE from this medicine than normal metabolizers. For example I'm taking 400 mg Progesteron orally every day and still get my period and PMS symptoms. It's ridiculous. 400 mg is what's prescribed to pregnant people, it's what gave the hormone its name.
Another substrate is a blood thinner like Warfarin. CYP grabs it and converts it into the effective drug. I need to get WAY LESS prescribed than a normal person otherwise I'll bleed out. Normal metabolizers only convert about 10% of Warfarin into its effective state. I do 60%. This needs to be on my medical record .
Here's a table with the known CYPs and on which substrates they work. Inhibitors and inducers are mentioned too: http://medicine.iupui.edu/clinpharm/ddis/main-table/
It's good to know how your CYPs are. It's especially important to know whether your homozygous for CYP2C19*17 because Progesteron plays such an important role in ME:
And I make sure to stay away from its inducers such as St. Johns worth and Prednison.
Somehow one of its inhibitors, hormonal contraceptives, made me truly mad so I stay away from those too. I guess my hormones are a sensitive balance and anything can throw it off.
Xeno-oestrogen such as soya; tofu; plastics and pesticides give me oestrogen symptoms right away too.
The combination of this enzym with a homozygous MAO A gene is precarious. MAO A destroys excitatory neurotransmitters (the catecholamines) which keep a person in Fight or Flight. Another enzym that destroys dopamine is COMT. With either of these enzymes not doing their work well you get a high strung, alert person. Who's permanently taxing his body, especially the adrenals.
Progesteron gives you just the opposite: a relaxed, mellow person.
Stupid CYP.
Ultrafast means my enzym metabolizes all its substrates superfast. Progesteron is such a substrate and CYP2C19*17 grabs it all from the blood and destroys it. I need to take MUCH MORE from this medicine than normal metabolizers. For example I'm taking 400 mg Progesteron orally every day and still get my period and PMS symptoms. It's ridiculous. 400 mg is what's prescribed to pregnant people, it's what gave the hormone its name.
Another substrate is a blood thinner like Warfarin. CYP grabs it and converts it into the effective drug. I need to get WAY LESS prescribed than a normal person otherwise I'll bleed out. Normal metabolizers only convert about 10% of Warfarin into its effective state. I do 60%. This needs to be on my medical record .
Here's a table with the known CYPs and on which substrates they work. Inhibitors and inducers are mentioned too: http://medicine.iupui.edu/clinpharm/ddis/main-table/
It's good to know how your CYPs are. It's especially important to know whether your homozygous for CYP2C19*17 because Progesteron plays such an important role in ME:
- it's the building block from which all cortisol is made in the adrenals.
- it's the one thing that helps when your MAO A gene is bust and you're running on high dopamine and noradrenaline (=norepinephrine). The catecholamines.
- it's needed to counter oestrogen in females. I've had oestrogen dominance all my life. PMS from hell.
And I make sure to stay away from its inducers such as St. Johns worth and Prednison.
Somehow one of its inhibitors, hormonal contraceptives, made me truly mad so I stay away from those too. I guess my hormones are a sensitive balance and anything can throw it off.
Xeno-oestrogen such as soya; tofu; plastics and pesticides give me oestrogen symptoms right away too.
The combination of this enzym with a homozygous MAO A gene is precarious. MAO A destroys excitatory neurotransmitters (the catecholamines) which keep a person in Fight or Flight. Another enzym that destroys dopamine is COMT. With either of these enzymes not doing their work well you get a high strung, alert person. Who's permanently taxing his body, especially the adrenals.
Progesteron gives you just the opposite: a relaxed, mellow person.
Stupid CYP.