Another potential vicious cycle:
http://www.ncbi.nlm.nih.gov/pubmed/8441757
Glutamate gets high, inhibits cystine transport, less cysteine available for glutathione, more glutamate hanging around with nowhere to go ...
I'm starting to see ME/CFS as a compelling argument for the theory of Intelligent Design
In rhesus macaques, cysteine levels decrease already within 1-2 weeks after infection with the closely related virus SIVmac. HIV-infected persons and SIV-infected rhesus macaques have also, on the average, substantially increased plasma glutamate levels. Increased glutamate levels aggravate the cysteine deficiency by inhibiting the membrane transport of cystine. Even moderately elevated extracellular glutamate levels as they occur in HIV-infected persons cause a substantial decrease of intracellular cysteine levels.
http://www.ncbi.nlm.nih.gov/pubmed/8441757
Glutamate gets high, inhibits cystine transport, less cysteine available for glutathione, more glutamate hanging around with nowhere to go ...
I'm starting to see ME/CFS as a compelling argument for the theory of Intelligent Design