@Jonathan Edwards in your (extremely) educated opinion is all this talk of methylation rubbish? All these people with their 23&me results and serious talk of their SNPs? It does seem like it could be a useful tool in pointing out weaknesses we can work round and compensate for.
I don't think he knows anything about methylation, and is just a bit of an habitual skeptic
But significant methylation mutations are no more common in ME patients than they are in everyone else, so it seems unlikely that they have anything to do with ME. The most common significant MTHFR mutations are easily compensated for by eating a decent amount of vegetables, or taking a normal multivitamin instead. And most SNPs focused upon by Yasko and reported by Genetic Genie are completely irrelevant - many are well-established as having no impact or a mild beneficial impact, despite being labeled +/+.
Richard Van Konyenburg (RichVanK) co-authored a proper scientific research trial of methylation support, and there weren't sustained benefits after some initial improvements. So it's not looking too good from that angle either. I suspect many people find B12 or folate to be beneficial in their own right, unrelated to methylation.
Very high doses of injected hydroxoB12 help with my pain quite a bit, for example, and I don't know if that has anything to do with being +/+ for MTRR A66G (30% of normal enzyme activity). I suspect it doesn't, because the dose is much larger than would be necessary to correct for a deficiency, and I should be getting plenty of B12 in my diet due to being a meat-lover.