NIH study suggests genetic Tryptase link for MCAS/EDS

[justy]

Previously Unexplained Symptoms Found Associated with Multiple Copies of a Single Gene
Monday, October 17, 2016
Scientists at the National Institutes of Health have identified a genetic explanation for a syndrome characterized by multiple frustrating and difficult-to-treat symptoms, including dizziness and lightheadedness, skin flushing and itching, gastrointestinal complaints, chronic pain, and bone and joint problems. Some people who experience these diverse symptoms have elevated levels of tryptase—a protein in the blood often associated with allergic reactions. Multiple copies of the alpha tryptase gene drive these tryptase elevations and may contribute to the symptoms, according to a new study led by investigators at NIH’s National Institute of Allergy and Infectious Diseases (NIAID).

https://www.niaid.nih.gov/news-even...over-genetic-explanation-frustrating-syndrome

 

[Cheesus]

There is a discussion about this here:

http://forums.phoenixrising.me/inde...ciated-with-ibs-hypermobility-pots-etc.47438/

 

[PeterPositive]

I am not sure if the study "proves" the genetic link but at least it suggests such link...

Although more research is needed to understand how elevated tryptase contributes to this constellation of symptoms, this study helps set the stage for future advances in diagnosis and treatment.

 

[taniaaust1]

https://www.niaid.nih.gov/news-even...over-genetic-explanation-frustrating-syndrome

is this link working for others? my computer is saying the link cant be found

 

[justy]

is this link working for others? my computer is saying the link cant be found

Its working for me - not sure about others.

I was going to delete the thread, but am leaving it here so it can be seen in the Mast cell forum.
@PeterPositive thanks - I will edit the thread name.