I work full time from home, and I constantly have to reassess whether it's a blessing or a curse. A month ago I was struggling to keep up, and was working extra on weekends and wearing myself out. I hadn't had significant cognitive impairment up until a couple of months ago, but I was beginning to feel it creep in.
A month or so ago I was planning to file for disability, but I had a sudden improvement in cognitive functioning after starting Low-Dose Naltrexone. I'd taken it briefly (and at a lower dose) months ago, but I didn't have significant cognitive problems at the time.
Whatever the reason, something improved and right now work is a great comfort to me because it keeps me focused on things other than my physical symptoms. I've had a lot of abdominal distress lately (I have SIBO and am on antibiotics for other things like chlamydia pneumoniae ). On days recently when my abdominal pain is really bad, in addition to my chronic pain, I am so grateful to be able to absorb myself in work, because I think I would probably sit and cry all day otherwise.
Having said all that, I could not work outside the home, at all. I only leave the house for doctors appointments and haircuts every couple of months, and those leave me wiped out for days. I should also note that I think the type of work I do is a good fit for someone in my situation. I manage a website that I edit throughout the day, and write and edit some of the content for it. I've been doing this specific job since 2008, and a lot of it is rote. I can log on in the morning and start completing tasks without having to concentrate too much. I have to participate in a couple of meetings by phone each week, which usually involve, "How are you feeling Kristen? Are you better? You sound great!" *sigh*
Another thing that I think is key if you're going to try to work from home is to get a good ergonomic set-up. Get a good desk with a keyboard tray, an adjustable office chair, and if you're working on a laptop attach a full-size monitor, keyboard and mouse. My first few months I worked at home I was using a laptop and started to get all sorts of back and hand pain from that.
I feel lucky right now to be able to work right now, but I've learned the hard way that everything can change from moment-to-moment with this, so we shall see.