There's nothing much to worry about there. The methylation SNPs that do something are -
COMT V158M does slow the enzyme but +/- would have a small effect. Supplementation with the cofactor magnesium could help to stimulate a sluggish enzyme.
There is no foundation to the Yasko stuff that COMT = too much dopamine and hence intolerance of methyl groups and that VDR Taq offsets this somehow since it lowers vit D which in turn stimulates dopamine production.
COMT and intolerance of methyl groups is pure speculation and plenty of people have put it to the test and found it not to be the case. Some people are sensitive to methyl groups but it has little to do with COMT.
VDR Taq affects the VDR, not vit D and actually has been shown to have little effect.
MTHFR A1298C does have a slight slowing of the enzyme but even +/+ is not great. Supplementation with the cofactor B2 and some methylfolate could be helpful.
The Yasko stuff about this SNP affecting the backwards reaction of the enzyme in which a molecule of BH4 is generated, and thus that the SNP compromises BH4, is yet another of her total misreadings of research.
The enzyme does not run backwards and it does not regenerate BH4, though methylfolate does act as a peroxynitrile scavenger so it could have a BH4 sparing effect.
The SNP simply has a small slowing effect on the normal (forward) action of the enzyme.
Here is a post about this SNP.
MTRR A66G and K350A do slow the enzyme but +/- would have a small effect. Some methylB12 could be helpful.
None of the other flagged SNPs have any effect to speak of.
Here is a recent thread which talks about some resources which can be helpful in understanding SNPs.
With the detox SNPs, often it is combinations that matter rather than individual SNPs. Promethease does a fair job in aligning SNP combinations with research about allele types affecting things like drug metabolism.
CYP 1B1L432V and CYP2D6 S486T for which you are +/+ should be checked carefully. I think these may well affect the metabolism of some drugs.
The first GSTP SNP could have some effect but you are +/- so not a big effect. Maybe make sure that glutathione precursors are in ample supply, plus adequate methylation can help with glutathionation. There are very mixed reports about direct glutathione supplementation. Some find it helpful, others a disaster.
The SOD2 doesn't do much.
NAT2 tends to be combinations. Promethease could help with that.